Faculty of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil.
BMC Cardiovasc Disord. 2013 Jun 21;13:44. doi: 10.1186/1471-2261-13-44.
Hypertension can be generated by a great number of mechanisms including elevated uric acid (UA) that contribute to the anion superoxide production. However, physical exercise is recommended to prevent and/or control high blood pressure (BP). The purpose of this study was to investigate the relationship between BP and UA and whether this relationship may be mediated by the functional fitness index.
All participants (n = 123) performed the following tests: indirect maximal oxygen uptake (VO2max), AAHPERD Functional Fitness Battery Test to determine the general fitness functional index (GFFI), systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI) and blood sample collection to evaluate the total-cholesterol (CHOL), LDL-cholesterol (LDL-c), HDL-cholesterol (HDL-c), triglycerides (TG), uric acid (UA), nitrite (NO2) and thiobarbituric acid reactive substances (T-BARS). After the physical, hemodynamic and metabolic evaluations, all participants were allocated into three groups according to their GFFI: G1 (regular), G2 (good) and G3 (very good).
Baseline blood pressure was higher in G1 when compared to G3 (+12% and +11%, for SBP and DBP, respectively, p<0.05) and the subjects who had higher values of BP also presented higher values of UA. Although UA was not different among GFFI groups, it presented a significant correlation with GFFI and VO2max. Also, nitrite concentration was elevated in G3 compared to G1 (140±29 μM vs 111±29 μM, for G3 and G1, respectively, p<0.0001). As far as the lipid profile, participants in G3 presented better values of CHOL and TG when compared to those in G1.
Taking together the findings that subjects with higher BP had elevated values of UA and lower values of nitrite, it can be suggested that the relationship between blood pressure and the oxidative stress produced by uric acid may be mediated by training status.
高血压可以由多种机制引起，包括尿酸（UA）升高，这有助于阴离子超氧化物的产生。然而，建议进行体育锻炼以预防和/或控制高血压（BP）。本研究的目的是调查 BP 与 UA 之间的关系，以及这种关系是否可能由功能健身指数介导。
所有参与者（n=123）进行了以下测试：间接最大摄氧量（VO2max）、AAHPERD 功能健身电池测试以确定一般健身功能指数（GFFI）、收缩压和舒张压（SBP 和 DBP）、体重指数（BMI）和血液样本采集以评估总胆固醇（CHOL）、低密度脂蛋白胆固醇（LDL-c）、高密度脂蛋白胆固醇（HDL-c）、甘油三酯（TG）、尿酸（UA）、亚硝酸盐（NO2）和硫代巴比妥酸反应物质（T-BARS）。在进行身体、血液动力学和代谢评估后，根据 GFFI 将所有参与者分为三组：G1（常规）、G2（良好）和 G3（非常好）。
与 G3 相比，G1 的基础血压更高（SBP 和 DBP 分别高 12%和 11%，p<0.05），血压较高的受试者 UA 值也较高。尽管 GFFI 组之间的 UA 没有差异，但它与 GFFI 和 VO2max 呈显著相关。此外，与 G1 相比，G3 中的亚硝酸盐浓度升高（G3 为 140±29 μM，G1 为 111±29 μM，p<0.0001）。就血脂谱而言，与 G1 相比，G3 组的 CHOL 和 TG 值更好。
综合考虑到高血压患者 UA 值升高和亚硝酸盐值降低的发现，可以认为尿酸产生的氧化应激与血压之间的关系可能受到训练状态的影响。
