Oderda G, Vaira D, Holton J, Ainley C, Altare F, Boero M, Smith A, Ansaldi N
Pediatric Gastroenterology Section, University of Turin, Italy.
Dig Dis Sci. 1991 May;36(5):572-6. doi: 10.1007/BF01297021.
Little is known about the source and spread of Helicobacter pylori, but transmission from infected family contacts has been suggested. We have therefore investigated 15 children with peptic ulcer and their first-degree relatives for H. pylori. Serum anti-H. pylori IgG, pepsinogen I, and gastrin levels were measured. Endoscopy was carried out on the children and relatives, and biopsies were taken from the gastric antrum for histology, microbiology, and urease testing. Six of 11 children with duodenal ulcer (55%) and two of four children with gastric ulcer (50%) were positive for H. pylori. Fourteen of 16 parents (87%) and eight of 13 siblings (61%) of H. pylori-positive children with peptic ulcer were also infected compared with eight of 14 parents (57%) and none of four siblings of H. pylori-negative children with peptic ulcer (P less than 0.10, greater than 0.05, and NS, respectively). The children with H. pylori-negative peptic ulcer and negative siblings combined were younger than positive children with peptic ulcer and positive siblings (P less than 0.001). The reliability of serum anti-H. pylori IgG level as a screening test for infection was confirmed. These findings call into question a pathogenetic role for H. pylori in some childhood peptic ulceration, but do suggest that person-to-person spread of infection occurs.
关于幽门螺杆菌的来源和传播知之甚少，但有观点认为它可通过受感染的家庭接触者传播。因此，我们对15名患有消化性溃疡的儿童及其一级亲属进行了幽门螺杆菌调查。检测了血清抗幽门螺杆菌IgG、胃蛋白酶原I和胃泌素水平。对儿童及其亲属进行了内镜检查，并从胃窦取活检组织进行组织学、微生物学和尿素酶检测。11名十二指肠溃疡患儿中有6名（55%）幽门螺杆菌检测呈阳性，4名胃溃疡患儿中有2名（50%）呈阳性。与幽门螺杆菌阴性的消化性溃疡患儿的14名父母中的8名（57%）和4名兄弟姐妹中的0名相比，幽门螺杆菌阳性的消化性溃疡患儿的16名父母中有14名（87%）和13名兄弟姐妹中有8名（61%）也受到了感染（P值分别小于0.10、大于0.05和无显著性差异）。幽门螺杆菌阴性的消化性溃疡患儿及其阴性的兄弟姐妹的组合比幽门螺杆菌阳性的消化性溃疡患儿及其阳性的兄弟姐妹年龄更小（P值小于0.001）。血清抗幽门螺杆菌IgG水平作为感染筛查试验的可靠性得到了证实。这些发现对幽门螺杆菌在某些儿童消化性溃疡中的致病作用提出了质疑，但确实表明感染存在人传人现象。
