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1
Early gene changes induced by isotretinoin in the skin provide clues to its mechanism of action.异维A酸在皮肤中诱导的早期基因变化为其作用机制提供了线索。
Dermatoendocrinol. 2009 Mar;1(2):100-1. doi: 10.4161/derm.1.2.8107.
2
Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action.接受异维甲酸治疗的患者皮肤中基因表达的时间变化为其作用机制提供了线索。
Dermatoendocrinol. 2009 May;1(3):177-87. doi: 10.4161/derm.1.3.8258.
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Activity of the type 1 5 alpha-reductase exhibits regional differences in isolated sebaceous glands and whole skin.1型5α-还原酶的活性在分离的皮脂腺和全皮中表现出区域差异。
J Invest Dermatol. 1995 Aug;105(2):209-14. doi: 10.1111/1523-1747.ep12317162.
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The effect of 13-cis-retinoic acid on sebaceous glands.13-顺式视黄酸对皮脂腺的作用。
Arch Dermatol. 1987 Nov;123(11):1538a-1541.
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Action of isotretinoin in acne rosacea and gram-negative folliculitis.异维A酸在玫瑰痤疮和革兰氏阴性菌毛囊炎中的作用。
J Am Acad Dermatol. 1982 Apr;6(4 Pt 2 Suppl):766-85. doi: 10.1016/s0190-9622(82)70067-2.
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13-cis-Retinoic acid in rosacea. Clinical and laboratory findings.13-顺式维甲酸治疗酒渣鼻。临床及实验室检查结果。
Acta Derm Venereol. 1984;64(1):15-21.
7
[Skin lipids in 13-cis-retinoic acid therapy of acne].[13-顺式维甲酸治疗痤疮中的皮肤脂质]
Z Hautkr. 1983 Dec 15;58(24):1743-53.
8
Comparative effect of isotretinoin and etretinate on acne and sebaceous gland secretion.异维A酸和维甲酸对痤疮及皮脂腺分泌的比较效果。
J Am Acad Dermatol. 1982 Apr;6(4 Pt 2 Suppl):760-5. doi: 10.1016/s0190-9622(82)70066-0.
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Isotretinoin. A review of its pharmacological properties and therapeutic efficacy in acne and other skin disorders.异维A酸。其药理学特性及在痤疮和其他皮肤疾病中的治疗效果综述。
Drugs. 1984 Jul;28(1):6-37. doi: 10.2165/00003495-198428010-00002.
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Differential effect of 13-cis-retinoic acid and an aromatic retinoid (Ro 10-9359) on the sebaceous glands of the hamster flank organ.
J Invest Dermatol. 1981 Jan;76(1):68-9. doi: 10.1111/1523-1747.ep12524899.

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1
Variation in pigmentation gene expression is associated with distinct aposematic color morphs in the poison frog Dendrobates auratus.色素基因表达的变异与毒蛙 Dendrobates auratus 的不同警戒色形态有关。
BMC Evol Biol. 2019 Apr 18;19(1):85. doi: 10.1186/s12862-019-1410-7.
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Transcriptional changes in organoculture of full-thickness human skin following topical application of all-trans retinoic acid.全厚层人皮肤经皮应用维 A 酸后的转录变化。
Int J Cosmet Sci. 2014 Jun;36(3):253-61. doi: 10.1111/ics.12121. Epub 2014 Mar 27.
3
Isotretinoin and FoxO1: A scientific hypothesis.异维A酸与FoxO1：一个科学假说。
Dermatoendocrinol. 2011 Jul;3(3):141-65. doi: 10.4161/derm.3.3.15331. Epub 2011 Jul 1.

本文引用的文献

1
TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN.脂溶性维生素缺乏后的组织变化。
J Exp Med. 1925 Nov 30;42(6):753-77. doi: 10.1084/jem.42.6.753.
2
Neutrophil gelatinase-associated lipocalin mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland cells.中性粒细胞明胶酶相关脂质运载蛋白介导13-顺式维甲酸诱导的人皮脂腺细胞凋亡。
J Clin Invest. 2008 Apr;118(4):1468-78. doi: 10.1172/JCI33869.
3
13-cis Retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes.13-顺式维甲酸诱导人SEB-1皮脂腺细胞凋亡和细胞周期停滞。
J Invest Dermatol. 2006 Oct;126(10):2178-89. doi: 10.1038/sj.jid.5700289. Epub 2006 Mar 30.
4
Gene array expression profiling in acne lesions reveals marked upregulation of genes involved in inflammation and matrix remodeling.痤疮皮损的基因芯片表达谱分析显示，参与炎症和基质重塑的基因显著上调。
J Invest Dermatol. 2006 May;126(5):1071-9. doi: 10.1038/sj.jid.5700213.
5
SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans.溶质载体家族24成员5（SLC24A5）是一种假定的阳离子交换剂，它会影响斑马鱼和人类的色素沉着。
Science. 2005 Dec 16;310(5755):1782-6. doi: 10.1126/science.1116238.
6
Systematic linkage disequilibrium analysis of SLC12A8 at PSORS5 confirms a role in susceptibility to psoriasis vulgaris.对位于寻常型银屑病易感区域5（PSORS5）的溶质载体家族12成员8（SLC12A8）进行系统的连锁不平衡分析，证实其在寻常型银屑病易感性中发挥作用。
J Invest Dermatol. 2005 Nov;125(5):906-12. doi: 10.1111/j.0022-202X.2005.23847.x.
7
DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation.胃癌中与视黄酸信号相关基因的DNA甲基化：维甲酸受体β、细胞视黄醇结合蛋白1和他扎罗汀诱导基因1的表达与DNA甲基化相关。
Cancer. 2005 Oct 15;104(8):1609-19. doi: 10.1002/cncr.21392.
8
DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage.食管鳞状细胞癌中与视黄酸信号相关基因的DNA甲基化：CRBP1和TIG1的DNA甲基化与肿瘤分期相关。
Cancer Sci. 2005 Sep;96(9):571-7. doi: 10.1111/j.1349-7006.2005.00082.x.
9
S100 proteins in the epidermis.表皮中的S100蛋白。
J Invest Dermatol. 2004 Jul;123(1):23-33. doi: 10.1111/j.0022-202X.2004.22719.x.
10
Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers.人类癌症中假定的肿瘤抑制基因他扎罗汀诱导基因1的高甲基化与沉默
Cancer Res. 2004 Apr 1;64(7):2411-7. doi: 10.1158/0008-5472.can-03-0164.

Early gene changes induced by isotretinoin in the skin provide clues to its mechanism of action.

作者信息

Nelson Amanda M, Zhao Wei, Gilliland Kathryn L, Zaenglein Andrea L, Liu Wenlei, Thiboutot Diane M

机构信息

The Jake Gittlen Cancer Research Foundation and Department of Dermatology; The Pennsylvania State University College of Medicine; Hershey, PA USA.

出版信息

Dermatoendocrinol. 2009 Mar;1(2):100-1. doi: 10.4161/derm.1.2.8107.

DOI:10.4161/derm.1.2.8107
PMID:20224692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2835899/
Abstract
摘要