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基于体外黏附和抗炎能力选择双歧杆菌改善小鼠结肠炎。

Selection of bifidobacteria based on adhesion and anti-inflammatory capacity in vitro for amelioration of murine colitis.

机构信息

Institute of Microbiology and Biotechnology, University of Ulm, Ulm, Germany.

出版信息

Appl Environ Microbiol. 2010 May;76(9):3048-51. doi: 10.1128/AEM.03127-09. Epub 2010 Mar 12.

DOI:10.1128/AEM.03127-09
PMID:20228095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2863435/
Abstract

Adhesion and anti-inflammatory properties of eight strains of bifidobacteria were tested using the intestinal epithelial cell lines Caco-2, T84, and HT29. Two strains were selected for further assessment of their anti-inflammatory capacity in two murine models of colitis. In vivo results confirmed the high anti-inflammatory capacity of a Bifidobacterium bifidum strain.

摘要

采用 Caco-2、T84 和 HT29 肠上皮细胞系测试了 8 株双歧杆菌的黏附和抗炎特性。选择了两株双歧杆菌进一步评估它们在两种结肠炎小鼠模型中的抗炎能力。体内结果证实了一株双歧杆菌的高抗炎能力。

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本文引用的文献

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2
Prevention of TNBS-induced colitis by different Lactobacillus and Bifidobacterium strains is associated with an expansion of gammadeltaT and regulatory T cells of intestinal intraepithelial lymphocytes.不同乳酸杆菌和双歧杆菌菌株预防三硝基苯磺酸诱导的结肠炎与肠道上皮内淋巴细胞的γδT细胞和调节性T细胞扩增有关。
Inflamm Bowel Dis. 2009 Oct;15(10):1526-36. doi: 10.1002/ibd.20961.
3
Mechanisms involved in alleviation of intestinal inflammation by bifidobacterium breve soluble factors.短双歧杆菌可溶性因子减轻肠道炎症的相关机制。
PLoS One. 2009;4(4):e5184. doi: 10.1371/journal.pone.0005184. Epub 2009 Apr 17.
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Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function.婴儿双歧杆菌分泌的生物活性因子可增强上皮细胞屏障功能。
Am J Physiol Gastrointest Liver Physiol. 2008 Nov;295(5):G1025-34. doi: 10.1152/ajpgi.90227.2008. Epub 2008 Sep 11.
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Commensal gut flora drives the expansion of proinflammatory CD4 T cells in the colonic lamina propria under normal and inflammatory conditions.共生肠道菌群在正常和炎症条件下驱动结肠固有层中促炎性CD4 T细胞的扩增。
J Immunol. 2008 Jan 1;180(1):559-68. doi: 10.4049/jimmunol.180.1.559.
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