Department of Physiological Chemistry and Cancer Genomics Centre, University Medical Center Utrecht, Stratenum 3.217, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands.
Cell Mol Life Sci. 2010 Jul;67(13):2145-61. doi: 10.1007/s00018-010-0321-y. Epub 2010 Mar 16.
Genomic stability requires error-free chromosome segregation during mitosis. Chromosome congression to the spindle equator precedes chromosome segregation in anaphase and is a hallmark of metazoan mitosis. Here we review the current knowledge and concepts on the processes that underlie chromosome congression, including initial attachment to spindle microtubules, biorientation, and movements, from the perspective of the kinetochore.
基因组稳定性要求有丝分裂过程中染色体的无差错分离。染色体向纺锤体赤道的汇聚先于后期的染色体分离，是后生动物有丝分裂的一个标志。在这里，我们从着丝粒的角度回顾了目前关于染色体汇聚的基础过程的知识和概念，包括与纺锤体微管的初始附着、双定向和运动。
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