体内和体外核小体定位的 DNA 序列依赖性。
The DNA sequence-dependence of nucleosome positioning in vivo and in vitro.
机构信息
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.
出版信息
J Biomol Struct Dyn. 2010 Jun;27(6):713-24. doi: 10.1080/073911010010524942.
Abstract
The contribution of histone-DNA interactions to nucleosome positioning in vivo is currently a matter of debate. We argue here that certain nucleosome positions, often in promoter regions, in yeast may be, at least in part, specified by the DNA sequence. In contrast other positions may be poorly specified. Positioning thus has both statistical and DNA-determined components. We further argue that the relative affinity of the octamer for different DNA sequences can vary and therefore the interaction of histones with the DNA is a 'tunable' property.
摘要
组蛋白-DNA 相互作用对体内核小体定位的贡献目前存在争议。我们在此认为，酵母中某些核小体位置（通常在启动子区域）至少部分由 DNA 序列决定。相比之下，其他位置可能没有明确的指定。因此，定位具有统计和 DNA 决定的成分。我们进一步认为，八聚体与不同 DNA 序列的相对亲和力可能会发生变化，因此组蛋白与 DNA 的相互作用是一种“可调”的特性。
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