INSERM, CIC 201, Lyon, Hospices Civils de Lyon, Service de Pharmacologie Clinique, Lyon, Université de Lyon, Lyon and CNRS, UMR 5558, Lyon, France.
Br J Clin Pharmacol. 2010 Feb;69(2):136-42. doi: 10.1111/j.1365-2125.2009.03574.x.
" Arnica montana is a popular homoeopathic treatment with potential haemostatic and anti-inflammatory properties. A homoeopathic combination of A. montana and Bryonia alba was used in aortic valve surgery to evaluate its effectiveness in reducing bleeding, inflammation, pain and myocardial ischaemia.
One day before surgery, 92 adult patients were randomly assigned to a double-blind parallel trial with either homoeopathic granules or a matching placebo until 4 days after surgery. The primary outcome was the volume of blood/liquid in the drains at their removal. The secondary outcomes included postoperative blood/liquid losses at 12 and 24 h as well as C-reactive protein (CRP), pain, temperature and plasma troponin Ic.
At 12 h and 24 h after surgery, then at drain removal, blood losses in homoeopathy and placebo groups were not statistically significant (362 +/- 218, 520 +/- 269 and 640 +/- 297 ml vs. 456 +/- 440, 620 +/- 477 and 796 +/- 717 ml; P= 0.19, 0.23 and 0.35, respectively). The statistical modelling did not show significantly different patterns of CRP, troponin and body temperature changes or of pain perception. The number of transfused packed red cells was not significantly different either (P= 0.58). Two patients from each group died during the study period and the number of serious adverse events was not statistically different (six in homoeopathy vs. 10 in placebo groups; Fisher's exact test P= 0.41).
In the study setting, there was no evidence of effects of A. montana and B. alba combination on bleeding, inflammation, pain or myocardial ischaemia.
“山金车是一种流行的顺势疗法治疗方法，具有潜在的止血和抗炎特性。在主动脉瓣手术中，使用山金车和白屈菜的顺势疗法组合来评估其减少出血、炎症、疼痛和心肌缺血的效果。
在手术前一天，92 名成年患者被随机分配到一项双盲平行试验中，分别接受顺势疗法颗粒或匹配的安慰剂治疗，直到手术后 4 天。主要结局是引流管移除时的出血量/液体量。次要结局包括手术后 12 小时和 24 小时的血液/液体丢失以及 C 反应蛋白（CRP）、疼痛、体温和血浆肌钙蛋白 Ic。
手术后 12 小时和 24 小时，以及引流管移除时，顺势疗法组和安慰剂组的出血量均无统计学意义（362 ± 218、520 ± 269 和 640 ± 297 ml 与 456 ± 440、620 ± 477 和 796 ± 717 ml；P=0.19、0.23 和 0.35）。统计模型未显示 CRP、肌钙蛋白和体温变化或疼痛感知的模式有显著差异。输注的浓缩红细胞数量也没有显著差异（P=0.58）。每组各有 2 名患者在研究期间死亡，严重不良事件的数量无统计学差异（顺势疗法组 6 例，安慰剂组 10 例；Fisher 确切检验 P=0.41）。
在研究环境中，山金车和白屈菜组合对出血、炎症、疼痛或心肌缺血没有影响。
