Stevinson C, Devaraj V S, Fountain-Barber A, Hawkins S, Ernst E
Department of Complementary Medicine, University of Exeter, UK.
J R Soc Med. 2003 Feb;96(2):60-5. doi: 10.1177/014107680309600203.
Homeopathic arnica is widely believed to control bruising, reduce swelling and promote recovery after local trauma; many patients therefore take it perioperatively. To determine whether this treatment has any effect, we conducted a double-blind, placebo-controlled, randomized trial with three parallel arms. 64 adults undergoing elective surgery for carpal tunnel syndrome were randomized to take three tablets daily of homeopathic arnica 30C or 6C or placebo for seven days before surgery and fourteen days after surgery. Primary outcome measures were pain (short form McGill Pain Questionnaire) and bruising (colour separation analysis) at four days after surgery. Secondary outcome measures were swelling (wrist circumference) and use of analgesic medication (patient diary). 62 patients could be included in the intention-to-treat analysis. There were no group differences on the primary outcome measures of pain (P=0.79) and bruising (P=0.45) at day four. Swelling and use of analgesic medication also did not differ between arnica and placebo groups. Adverse events were reported by 2 patients in the arnica 6C group, 3 in the placebo group and 4 in the arnica 30C group. The results of this trial do not suggest that homeopathic arnica has an advantage over placebo in reducing postoperative pain, bruising and swelling in patients undergoing elective hand surgery.
顺势疗法山金车被广泛认为可控制瘀伤、减轻肿胀并促进局部创伤后的恢复；因此，许多患者在围手术期服用它。为了确定这种治疗是否有任何效果，我们进行了一项双盲、安慰剂对照、随机试验，设有三个平行组。64名接受腕管综合征择期手术的成年人被随机分为三组，在手术前7天和手术后14天，每天服用三片顺势疗法30C或6C山金车或安慰剂。主要结局指标是术后4天的疼痛（简短麦吉尔疼痛问卷）和瘀伤（颜色分离分析）。次要结局指标是肿胀（腕围）和镇痛药物使用情况（患者日记）。62名患者可纳入意向性分析。在第4天，疼痛（P=0.79）和瘀伤（P=0.45）的主要结局指标在各组之间没有差异。山金车组和安慰剂组之间的肿胀和镇痛药物使用情况也没有差异。6C山金车组有2名患者、安慰剂组有3名患者和30C山金车组有4名患者报告了不良事件。该试验结果表明，在接受择期手部手术的患者中，顺势疗法山金车在减轻术后疼痛、瘀伤和肿胀方面并不比安慰剂有优势。
