Lou H, Ding W, Dong M, Zhu Y, Zhou C, Wang Z, Yang X, Yao Q, Li D, Miao M
Department of Obstetrics, Zhejiang University, Hangzhou, China.
J Int Med Res. 2010 Jan-Feb;38(1):214-9. doi: 10.1177/147323001003800125.
Vertical transmission of hepatitis B virus (HBV) has been proposed to play an important role in mother-to-child transmission, although the extent to which vertical transmission via oocytes contributes to neonatal HBV infection remains unknown. Ovarian biopsies were collected during caesarean sections in 68 clinically asymptomatic pregnant women who were carriers of HBV. The presence of hepatitis B surface antigen (HBsAg) in the ova of pregnant women was determined by immunohistochemistry. Serum markers of HBV infection in pregnant women and their neonates were analysed. It was found that, of 68 women, the ova were positive for HBsAg in only one woman and her neonate was negative for any serum HBV markers 3 days after birth. Of 68 neonates, one was positive for serum HBV markers 3 days after birth and his mother's ova were negative for HBsAg. These findings indicate that vertical transmission via oocytes may not be the major route of HBV intra-uterine infection.
乙型肝炎病毒（HBV）的垂直传播被认为在母婴传播中起重要作用，尽管通过卵母细胞的垂直传播对新生儿HBV感染的影响程度尚不清楚。在剖宫产期间收集了68名临床无症状的HBV携带者孕妇的卵巢活检组织。通过免疫组织化学法检测孕妇卵子中乙型肝炎表面抗原（HBsAg）的存在情况。分析了孕妇及其新生儿的HBV感染血清标志物。结果发现，在68名妇女中，只有一名妇女的卵子HBsAg呈阳性，其新生儿出生3天后任何血清HBV标志物均为阴性。在68名新生儿中，一名新生儿出生3天后血清HBV标志物呈阳性，而其母亲的卵子HBsAg为阴性。这些发现表明，通过卵母细胞的垂直传播可能不是HBV宫内感染的主要途径。
