Department of Obstetrics and Gynecology, Second Affiliated Hospital of Southeast University, Nanjing, Jiangsu Province, China.
PLoS One. 2013;8(1):e54246. doi: 10.1371/journal.pone.0054246. Epub 2013 Jan 31.
The aim of this study was to investigate the correlation between the expression of hepatitis B surface antigen (HBsAg) in human ovary and placenta and the vertical transmission of hepatitis B virus (HBV).
METHODOLOGY/PRINCIPAL FIDNINGS: Ovarian and placental tissue specimens of pregnant women infected with HBV were collected during cesarean section and immunostained for HBsAg. The sera of the corresponding newborns were tested for HBV markers and HBV DNA. HBsAg was detected in 15 out of 33 (45%) placental tissues and was further detected in capillary endothelial cells in 4 specimens (26%), of which 3 (75%) corresponding infants were infected with HBV in utero. Out of the 33 ovarian tissues, 7 (21%) were positive for HBsAg, of which 2 (28%) showed HBsAg in ovarian follicles and the 2 corresponding infants (100%) had intrauterine HBV infection.
CONCLUSIONS/SIGNIFICANCE: HBsAg expression in cells of the ovarian follicle or placental capillary endothelium signal a higher risk for intrauterine HBV infection.
本研究旨在探讨乙型肝炎表面抗原（HBsAg）在人卵巢和胎盘组织中的表达与乙型肝炎病毒（HBV）垂直传播之间的关系。
方法/主要发现：在剖宫产术中收集了感染 HBV 的孕妇的卵巢和胎盘组织标本，并进行 HBsAg 免疫染色。对相应新生儿的血清进行 HBV 标志物和 HBV DNA 检测。在 33 个胎盘组织中有 15 个（45%）检测到 HBsAg，其中 4 个标本（26%）进一步在毛细血管内皮细胞中检测到 HBsAg，其中 3 个（75%）对应的婴儿在宫内感染了 HBV。在 33 个卵巢组织中，有 7 个（21%）检测到 HBsAg，其中 2 个（28%）在卵巢滤泡中显示 HBsAg，这 2 个对应的婴儿（100%）在宫内感染了 HBV。
结论/意义：卵巢滤泡或胎盘毛细血管内皮细胞中 HBsAg 的表达提示宫内 HBV 感染的风险更高。
