有照料者剥夺和情感忽视史的青少年内侧颞叶功能的初步研究。
A preliminary study of medial temporal lobe function in youths with a history of caregiver deprivation and emotional neglect.
机构信息
Research Centre of the CHU Ste-Justine, Montreal, Quebec, Canada.
出版信息
Cogn Affect Behav Neurosci. 2010 Mar;10(1):34-49. doi: 10.3758/CABN.10.1.34.
Abstract
Previous research findings have linked caregiver deprivation and emotional neglect with sensitivity to threatening cues. The present preliminary study investigated whether dysfunctions of the medial temporal lobe could underlie these associations. Using fMRI, we measured medial temporal lobe responses to emotional faces (angry, fearful, happy, neutral) among 30 youths. Eleven of the youths had a history of caregiver deprivation and emotional neglect. Attention states (i.e., attention to anger, fear, or physical attributes, or passive viewing) were systematically manipulated. Relative to comparison youths, youths with a history of caregiver deprivation and emotional neglect showed significantly greater left amygdala and left anterior hippocampus activation during the processing of threatening information. To our knowledge, these findings are the first to demonstrate altered medial temporal lobe function during the processing of threat cues in youths with a history of caregiver deprivation and emotional neglect.
摘要
先前的研究发现，照顾者剥夺和情感忽视与对威胁线索的敏感性有关。本初步研究探讨了内侧颞叶功能障碍是否是这些关联的基础。使用 fMRI，我们测量了 30 名年轻人对情绪面孔（愤怒、恐惧、快乐、中性）的内侧颞叶反应。其中 11 名年轻人有照顾者剥夺和情感忽视的病史。注意力状态（即注意愤怒、恐惧或身体特征，或被动观察）被系统地操纵。与对照组年轻人相比，有照顾者剥夺和情感忽视病史的年轻人在处理威胁信息时，左侧杏仁核和左侧前海马体的激活明显更大。据我们所知，这些发现首次表明，在有照顾者剥夺和情感忽视病史的年轻人中，内侧颞叶在处理威胁线索时的功能发生了改变。
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