Van Noord J A, Clément J, Van de Woestijne K P, Demedts M
Clinic for Pneumology, Catholic University, Leuven, Belgium.
Am Rev Respir Dis. 1991 May;143(5 Pt 1):922-7. doi: 10.1164/ajrccm/143.5_Pt_1.922.
A comparison was made of total respiratory resistance (Rrs) and reactance (Xrs) determined between 6 and 26 Hz by means of a forced oscillation technique in 27 patients with asthma (group A), 28 patients with chronic bronchitis (group B), and 20 patients with emphysema (group E) to examine whether the method can provide data capable of distinguishing among these diseases. The three groups demonstrated a similar reduction in the FEV1. In addition, static and dynamic lung volumes, maximal expiratory flows, diffusing capacity for CO, airway resistance (Raw), and elastic lung recoil were measured. The observed alterations of Rrs and Xrs consisted of an increase in Rrs, a decrease in Rrs with frequency, and a decrease in Xrs. However, significant differences were found between the three groups: Rrs at 6 Hz and average Rrs were most increased in group A, whereas the negative frequency dependence of Rrs and the decrease in Xrs were least pronounced in group E. In all groups Rrs at 6 Hz, the average slope of Rrs, and the average level of Xrs were tightly interrelated and showed in addition a high correlation with airway resistance; the correlations with FEV1 were less satisfactory. Discriminant analysis performed on the complete set of data, excluding diffusing capacity and elastic lung recoil, which were used as selection criteria, demonstrated that forced oscillation parameters were the most important factors discriminating among the groups.
采用强迫振荡技术，对27例哮喘患者（A组）、28例慢性支气管炎患者（B组）和20例肺气肿患者（E组）在6至26Hz之间测定的总呼吸阻力（Rrs）和电抗（Xrs）进行比较，以检验该方法能否提供能够区分这些疾病的数据。三组患者的第一秒用力呼气容积（FEV1）均有相似程度的降低。此外，还测量了静态和动态肺容量、最大呼气流量、一氧化碳弥散量、气道阻力（Raw）和肺弹性回缩力。观察到的Rrs和Xrs的变化包括Rrs增加、Rrs随频率降低以及Xrs降低。然而，三组之间存在显著差异：A组6Hz时的Rrs和平均Rrs增加最为明显，而E组Rrs的负频率依赖性和Xrs的降低最不明显。在所有组中，6Hz时的Rrs、Rrs的平均斜率和Xrs的平均水平紧密相关，并且与气道阻力也呈现出高度相关性；与FEV1的相关性则不太理想。对完整数据集进行判别分析（排除用作选择标准的弥散量和肺弹性回缩力）表明，强迫振荡参数是区分各组的最重要因素。
