Harrison L H, Armstrong C W, Jenkins S R, Harmon M W, Ajello G W, Miller G B, Broome C V
Meningitis and Special Pathogens Branch, Centers for Disease Control, Atlanta, GA 30333.
Arch Intern Med. 1991 May;151(5):1005-9.
An outbreak of meningococcal disease among children on a school bus offered the opportunity to study a proposed association between this infection and preceding influenza infection. Five students who rode the bus became ill with invasive group C meningococcus. Transmission was limited to the bus; there was no evidence for school transmission. All five students reported influenza-like symptoms within several weeks before the development of meningococcal disease. School absenteeism, principally due to upper respiratory tract illness, was higher during the 3 weeks before the outbreak of meningococcal disease than during any period in the preceding 3 1/2 years, suggesting an unusually severe outbreak of respiratory illness. A case-control study comparing students with and without influenza symptoms revealed that the outbreak of respiratory disease was due to B/Ann Arbor/1/86 influenza (geometric mean titers, 86 for 80 patients and 33 for 47 controls [P = .0007]). These data add to the evidence suggesting that influenza respiratory infection predisposes to meningococcal disease.
一辆校车上的儿童中爆发了脑膜炎球菌病，这为研究这种感染与先前流感感染之间的假定关联提供了机会。乘坐这辆校车的五名学生感染了侵袭性C群脑膜炎球菌。传播仅限于这辆校车；没有证据表明疾病在学校内传播。所有五名学生在患脑膜炎球菌病前几周都出现了流感样症状。主要由于上呼吸道疾病导致的学校缺勤率，在脑膜炎球菌病爆发前的3周高于此前3年半的任何时期，表明呼吸道疾病爆发异常严重。一项比较有和没有流感症状学生的病例对照研究表明，呼吸道疾病爆发是由B/安阿伯/1/86流感引起的（几何平均滴度，80名患者为86，47名对照为33 [P = .0007]）。这些数据进一步证明，流感呼吸道感染易引发脑膜炎球菌病。
