口蹄疫病毒微量中和试验中的剂量-反应关系。
Dose-response relationships in a microneutralization test for foot-and-mouth disease viruses.
作者信息
Booth J C, Rweyemamu M M, Pay T W
出版信息
J Hyg (Lond). 1978 Feb;80(1):31-42. doi: 10.1017/s0022172400053377.
Abstract
Two-dimensional quantal microneutralization tests on foot-and-mouth disease viruses, in which neutralizing antibody activity was titrated against a serial range of virus doses, demonstrated a variety of dose-response curves some of which were rectilinear, others clearly curvilinear. Moreover, in the case of the non-linear responses obtained with some antisera, the shape of the curve was such that antibody titres recorded with doses of virus ranging from 10(3)-10(5) TCD50 were closely similar. Studies were carried out on the effect of varying the conditions of the test on the shape of the dose-response curve: significant differences were obtained after treatment of the antiserum-virus mixtures with anti-species globulin, and when the test was assayed in cells of differing susceptibility to infection.
摘要
针对口蹄疫病毒的二维定量微量中和试验，其中针对一系列连续的病毒剂量滴定中和抗体活性，显示出多种剂量反应曲线，其中一些是直线型的，另一些则明显是曲线型的。此外，在用某些抗血清获得非线性反应的情况下，曲线的形状使得用10(3)-10(5) TCD50的病毒剂量记录的抗体滴度非常相似。开展了关于改变试验条件对剂量反应曲线形状影响的研究：在用抗种属球蛋白处理抗血清-病毒混合物后，以及在对感染敏感性不同的细胞中进行试验时，均获得了显著差异。
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本文引用的文献
1
PURIFICATION OF RADIOACTIVE FOOT-AND-MOUTH DISEASE VIRUS.放射性口蹄疫病毒的纯化
Nature. 1963 Sep 21;199:1168-70. doi: 10.1038/1991168a0.
2
THE USE OF ACETYLETHYLENEIMINE IN THE PRODUCTION OF INACTIVATED FOOT-AND-MOUTH DISEASE VACCINES.乙酰亚乙基胺在口蹄疫灭活疫苗生产中的应用。
J Hyg (Lond). 1963 Sep;61(3):337-44. doi: 10.1017/s0022172400039620.
3
Influence of host cell on residual infectivity of neutralized vesicular stomatitis virus.宿主细胞对中和的水疱性口炎病毒残余感染性的影响。
Virology. 1959 Feb;7(2):236-9. doi: 10.1016/0042-6822(59)90189-8.
4
An improved assay method for neutralizing antibodies against influenza viruses.一种改进的针对流感病毒的中和抗体检测方法。
J Hyg (Lond). 1958 Sep;56(3):415-26. doi: 10.1017/s0022172400037906.
5
Neutralization of viruses by homologous immune serum. I. Quantitative studies on factors which affect the neutralization reaction with Newcastle disease, influenza A, and bacterial virus T3.同源免疫血清对病毒的中和作用。I. 影响新城疫病毒、甲型流感病毒和细菌病毒T3中和反应因素的定量研究
J Exp Med. 1953 Jun;97(6):845-61. doi: 10.1084/jem.97.6.845.
6
Infectious antibody-reovirus complexes.感染性抗体-呼肠孤病毒复合物
Infect Immun. 1972 Dec;6(6):996-1002. doi: 10.1128/iai.6.6.996-1002.1972.
7
Virus aggregation as the cause of the non-neutralizable persistent fraction.病毒聚集作为不可中和的持续性组分的原因。
J Virol. 1967 Jun;1(3):478-88. doi: 10.1128/JVI.1.3.478-488.1967.
8
Effect of anticellular serum on the attachment of enteroviruses to HeLa cells.抗细胞血清对肠道病毒吸附于HeLa细胞的影响。
J Virol. 1968 Aug;2(8):813-21. doi: 10.1128/JVI.2.8.813-821.1968.
9
Nature of the inactivating action of trypsin on foot-and-mouth disease virus.胰蛋白酶对口蹄疫病毒的灭活作用性质
J Gen Virol. 1967 Apr;1(2):247-50. doi: 10.1099/0022-1317-1-2-247.
10
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Med Microbiol Immunol. 1973 Sep 26;159(1):73-82. doi: 10.1007/BF02122651.
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