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Helvecardins A and B, novel glycopeptide antibiotics. I. Taxonomy, fermentation, isolation and physico-chemical properties.

作者信息

Takeuchi M, Enokita R, Okazaki T, Kagasaki T, Inukai M

机构信息

Fermentation Research Laboratories, Sankyo Co, Ltd., Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1991 Mar;44(3):263-70. doi: 10.7164/antibiotics.44.263.

DOI:10.7164/antibiotics.44.263
PMID:2026550
Abstract

A strain of actinomycetes identified as Pseudonocardia compacta subsp. helvetica produced new glycopeptide antibiotics, helvecardins A and B. They were isolated from culture broth mainly by affinity chromatography of D-alanyl-D-alanine and preparative HPLC. The physico-chemical properties of helvecardins A and B showed that they resemble each other. Though helvecardin A was structurally related to beta-avoparcin, it clearly differed in the presence of an O-methyl moiety in its NMR spectrum.

摘要

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