东方拟无枝酸菌新菌株产生的糖肽抗生素MM 47761和MM 49721。分离、纯化及结构测定。

MM 47761 and MM 49721, glycopeptide antibiotics produced by a new strain of Amycolatopsis orientalis. Isolation, purification and structure determination.

作者信息

Box S J, Elson A L, Gilpin M L, Winstanley D J

机构信息

Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Betchworth, Surrey, UK.

出版信息

J Antibiot (Tokyo). 1990 Aug;43(8):931-7. doi: 10.7164/antibiotics.43.931.

DOI:10.7164/antibiotics.43.931

PMID:2120168

Abstract

Two glycopeptide antibiotics MM 47761 and MM 47921 have been isolated from Amycolatopsis orientalis NCIB 12608. Fermentation conditions for their production, and methods for their isolation are described. The metabolites have been characterised by physio-chemical and biological properties and the structure determined by a combination of chemical degradation, COSY and NOE NMR studies. Both metabolites showed good antibacterial activity against Gram-positive organisms.

摘要

已从东方拟无枝酸菌NCIB 12608中分离出两种糖肽抗生素MM 47761和MM 47921。描述了它们的生产发酵条件及其分离方法。通过物理化学和生物学特性对这些代谢产物进行了表征，并通过化学降解、COSY和NOE核磁共振研究相结合的方法确定了其结构。两种代谢产物对革兰氏阳性菌均显示出良好的抗菌活性。