Bennet R, Eriksson M, Tafari N, Nord C E
Department of Pediatrics, Karolinska Institute, St. Göran's Children's Hospital, Stockholm, Sweden.
Scand J Infect Dis. 1991;23(1):63-9. doi: 10.3109/00365549109023376.
The aerobic and anaerobic intestinal microflora of 60 newborn infants in Addis Ababa was studied. As opposed to earlier published studies from Stockholm, there were no consistent changes of the microflora attributable to antibiotic treatment. The reason why antimicrobial agents caused quantitatively smaller changes of the intestinal microflora in newborn infants in Addis Ababa than in Stockholm is not known, but may be due to antimicrobial inactivation, or marked, continuous ingestion of bacteria. Colonisation by potentially pathogenic gram-negative bacteria was coupled to a low isolation rate of bifidobacterium, but not of lactobacillus. This is consistent with the hypothesis that bifidobacterium might convey some kind of resistance to colonisation by and overgrowth of gram-negative bacteria in newborn infants. Similar results have previously been obtained in Stockholm. In comparison to 45 healthy infants in Stockholm, the Ethiopian infants had more enterococcus and lactobacillus and less staphylococcus and bacteroides during the first 2 weeks of life. After that time, the only difference was more frequent colonisation by lactobacillus in Addis Ababa.
对亚的斯亚贝巴60名新生儿的需氧和厌氧肠道微生物群进行了研究。与斯德哥尔摩早期发表的研究结果相反，抗生素治疗并未导致微生物群出现一致的变化。抗菌药物在亚的斯亚贝巴新生儿中引起的肠道微生物群数量变化比在斯德哥尔摩小，原因尚不清楚，但可能是由于抗菌药物失活，或婴儿持续大量摄入细菌。潜在致病革兰氏阴性菌的定植与双歧杆菌的低分离率相关，但与乳酸杆菌无关。这与以下假设一致，即双歧杆菌可能对新生儿革兰氏阴性菌的定植和过度生长具有某种抵抗力。此前在斯德哥尔摩也得到了类似结果。与斯德哥尔摩的45名健康婴儿相比，埃塞俄比亚婴儿在出生后的前两周内肠球菌和乳酸杆菌更多，葡萄球菌和拟杆菌更少。在那之后，唯一的差异是亚的斯亚贝巴的婴儿中乳酸杆菌定植更为频繁。
