Lode H
Department of Pneumology and Infectious Diseases, World Health Organization Center for Respiratory Infections, Krankenhaus Berlin-Zehlendorf, Germany.
Clin Ther. 1991 Jan-Feb;13(1):149-56; discussion 148.
Antibiotic therapy of purulent bronchitis is a matter of continuing controversy. However, recent studies on the pathogenicity of airway hyperreactivity, granulocyte-mediated bronchial obstruction, and histamine production of Haemophilus influenzae indicate an important role for viral and bacterial infections in exacerbations of chronic obstructive lung disease (COLD). Considering the different stages of COLD in relation to lung function, bacterial pathogens, and relevant findings and symptoms of the individual patient, antibiotic treatment should be based on three different degrees of severity.
化脓性支气管炎的抗生素治疗一直存在争议。然而，最近关于气道高反应性的致病性、粒细胞介导的支气管阻塞以及流感嗜血杆菌组胺产生的研究表明，病毒和细菌感染在慢性阻塞性肺疾病（COLD）加重过程中起着重要作用。考虑到COLD在肺功能、细菌病原体以及个体患者相关检查结果和症状方面的不同阶段，抗生素治疗应基于三种不同的严重程度。
