昼夜节律钟与血管功能。
Circadian clocks and vascular function.
机构信息
Department of Pharmacology, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104-6084.
出版信息
Circ Res. 2010 Mar 19;106(5):833-41. doi: 10.1161/CIRCRESAHA.109.211706.
Abstract
The circadian clock regulates many aspects of physiology, including cardiovascular function. Internal oscillators exist in endothelial, smooth muscle cells, and fibroblasts of the vasculature. Vascular tone and thrombus formation, 2 key elements of vascular function with regard to adverse cardiovascular events, exhibit diurnal rhythmicity. In this review, we describe changes in vascular function that result from genetic disruption of discrete elements of the circadian clock.
摘要
生物钟调节着许多生理方面，包括心血管功能。内源性振荡器存在于血管的内皮细胞、平滑肌细胞和成纤维细胞中。血管张力和血栓形成是与不良心血管事件相关的血管功能的 2 个关键要素，表现出昼夜节律性。在这篇综述中，我们描述了由于生物钟离散元件的遗传破坏而导致的血管功能变化。
相似文献
1
Circadian clocks and vascular function.昼夜节律钟与血管功能。
Circ Res. 2010 Mar 19;106(5):833-41. doi: 10.1161/CIRCRESAHA.109.211706.
2
Peripheral circadian clocks in the vasculature.血管系统中的外周生物钟。
Arterioscler Thromb Vasc Biol. 2007 Aug;27(8):1694-705. doi: 10.1161/ATVBAHA.107.144923. Epub 2007 May 31.
3
Vasculature on the clock: Circadian rhythm and vascular dysfunction.时钟上的脉管系统：昼夜节律与血管功能障碍。
Vascul Pharmacol. 2018 Sep;108:1-7. doi: 10.1016/j.vph.2018.05.003. Epub 2018 May 17.
4
Circadian rhythms and the molecular clock in cardiovascular biology and disease.昼夜节律和分子钟在心血管生物学和疾病中的作用。
Nat Rev Cardiol. 2019 Jul;16(7):437-447. doi: 10.1038/s41569-019-0167-4.
5
The Vascular Circadian Clock in Chronic Kidney Disease.慢性肾脏病中的血管生物钟。
Cells. 2021 Jul 13;10(7):1769. doi: 10.3390/cells10071769.
6
[Clock genes and circadian rhythm of blood pressure].[时钟基因与血压的昼夜节律]
Nihon Rinsho. 2014 Aug;72(8):1354-60.
7
Circadian clock and vascular disease.生物钟与血管疾病。
Hypertens Res. 2010 Jul;33(7):645-51. doi: 10.1038/hr.2010.68. Epub 2010 May 7.
8
Rapid attenuation of circadian clock gene oscillations in the rat heart following ischemia-reperfusion.缺血再灌注后大鼠心脏中昼夜节律时钟基因振荡的快速衰减。
J Mol Cell Cardiol. 2007 Dec;43(6):744-53. doi: 10.1016/j.yjmcc.2007.08.018. Epub 2007 Sep 5.
9
Central and peripheral clocks in cardiovascular and metabolic function.心血管和代谢功能中的中枢和外周生物钟
Ann Med. 2006;38(8):552-9. doi: 10.1080/07853890600995010.
10
The mammalian circadian clock: a network of gene expression.哺乳动物的生物钟：一个基因表达网络。
Front Biosci. 2004 Jan 1;9:48-55. doi: 10.2741/1196.
引用本文的文献
1
Sleep Irregularity, Circadian Disruption, and Cardiometabolic Disease Risk.睡眠不规律、昼夜节律紊乱与心脏代谢疾病风险
Circ Res. 2025 Aug 15;137(5):709-726. doi: 10.1161/CIRCRESAHA.125.325613. Epub 2025 Aug 14.
2
Sustained Accumulation of Molecular Clock Suppressors Period 1 and Period 2 Promotes C2C12 Myotube Atrophy Through an Autocrine-Mediated Mechanism With Relevance to Androgen Deprivation-Induced Limb Muscle Mass Loss.分子时钟抑制因子Period 1和Period 2的持续积累通过自分泌介导机制促进C2C12肌管萎缩，这与雄激素剥夺诱导的肢体肌肉质量损失相关。
Function (Oxf). 2025 Aug 1;6(4). doi: 10.1093/function/zqaf030.
3
The effect of transient sex hormone fluctuations on vascular endothelial function.短暂性激素波动对血管内皮功能的影响。
Am J Physiol Heart Circ Physiol. 2025 Jul 1;329(1):H217-H232. doi: 10.1152/ajpheart.00174.2025. Epub 2025 Jun 3.
4
BRIGHTening growth hormone delivery.优化生长激素递送。
Nat Mater. 2025 May 23. doi: 10.1038/s41563-025-02237-3.
5
Circadian influences on sudden cardiac death and cardiac electrophysiology.昼夜节律对心源性猝死和心脏电生理学的影响。
J Mol Cell Cardiol. 2025 Mar;200:93-112. doi: 10.1016/j.yjmcc.2025.01.006. Epub 2025 Jan 27.
6
CLOCK gene 3'UTR and exon 9 polymorphisms show a strong association with essential hypertension in a North Indian population.时钟基因3'非翻译区和外显子9多态性与北印度人群的原发性高血压密切相关。
BMC Med Genomics. 2024 Dec 18;17(1):289. doi: 10.1186/s12920-024-02056-6.
7
Complement Immune System in Pulmonary Hypertension-Cooperating Roles of Circadian Rhythmicity in Complement-Mediated Vascular Pathology.肺动脉高压中的补体免疫系统——昼夜节律在补体介导的血管病理中的协同作用
Int J Mol Sci. 2024 Nov 28;25(23):12823. doi: 10.3390/ijms252312823.
8
Circadian Dysfunction in the Skeletal Muscle Impairs Limb Perfusion and Muscle Regeneration in Peripheral Artery Disease.骨骼肌中的昼夜节律功能障碍会损害外周动脉疾病中的肢体灌注和肌肉再生。
Arterioscler Thromb Vasc Biol. 2025 Feb;45(2):e30-e47. doi: 10.1161/ATVBAHA.124.321772. Epub 2024 Dec 5.
9
Evaluating the reproducibility of a deep learning algorithm for the prediction of retinal age.评估用于预测视网膜年龄的深度学习算法的可重复性。
Geroscience. 2025 Apr;47(2):2541-2554. doi: 10.1007/s11357-024-01445-0. Epub 2024 Nov 26.
10
Diabetic Neuropathic Pain and Circadian Rhythm: A Future Direction Worthy of Study.糖尿病性神经病理性疼痛与昼夜节律：一个值得研究的未来方向。
J Pain Res. 2024 Sep 16;17:3005-3020. doi: 10.2147/JPR.S467249. eCollection 2024.
本文引用的文献
1
Effects of poor and short sleep on glucose metabolism and obesity risk.睡眠不足和睡眠质量差对葡萄糖代谢及肥胖风险的影响。
Nat Rev Endocrinol. 2009 May;5(5):253-61. doi: 10.1038/nrendo.2009.23.
2
Harmonics of circadian gene transcription in mammals.哺乳动物昼夜节律基因转录的谐波
PLoS Genet. 2009 Apr;5(4):e1000442. doi: 10.1371/journal.pgen.1000442. Epub 2009 Apr 3.
3
Vascular disease in mice with a dysfunctional circadian clock.生物钟功能失调的小鼠的血管疾病
Circulation. 2009 Mar 24;119(11):1510-7. doi: 10.1161/CIRCULATIONAHA.108.827477. Epub 2009 Mar 9.
4
Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1.血管中的过氧化物酶体增殖物激活受体γ（PPARγ）通过Bmal1控制血压和心率的昼夜变化。
Cell Metab. 2008 Dec;8(6):482-91. doi: 10.1016/j.cmet.2008.10.009.
5
Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2.昼夜节律基因Per2突变介导的血管衰老增加和内皮祖细胞功能受损。
Circulation. 2008 Nov 18;118(21):2166-73. doi: 10.1161/CIRCULATIONAHA.108.790469. Epub 2008 Nov 3.
6
Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt.血管内皮生长因子受体-1通过抑制Akt的过度激活来调节出生后的血管生成。
Circ Res. 2008 Aug 1;103(3):261-8. doi: 10.1161/CIRCRESAHA.108.174128. Epub 2008 Jun 26.
7
Genetic components of the circadian clock regulate thrombogenesis in vivo.生物钟的遗传成分在体内调节血栓形成。
Circulation. 2008 Apr 22;117(16):2087-95. doi: 10.1161/CIRCULATIONAHA.107.739227. Epub 2008 Apr 14.
8
Reduced nitric oxide causes age-associated impairment of circadian rhythmicity.
Circ Res. 2008 Mar 14;102(5):607-14. doi: 10.1161/CIRCRESAHA.107.162230. Epub 2008 Jan 24.
9
Peripheral circadian clock rhythmicity is retained in the absence of adrenergic signaling.在缺乏肾上腺素能信号传导的情况下，外周昼夜节律时钟的节律性得以保留。
Arterioscler Thromb Vasc Biol. 2008 Jan;28(1):121-6. doi: 10.1161/ATVBAHA.107.152538. Epub 2007 Nov 1.
10
Thrombomodulin is a clock-controlled gene in vascular endothelial cells.血栓调节蛋白是血管内皮细胞中的一个生物钟调控基因。
J Biol Chem. 2007 Nov 9;282(45):32561-7. doi: 10.1074/jbc.M705692200. Epub 2007 Sep 11.
Zotero 插件