Frye Richard E, Butler Ian, Strickland David, Castillo Edwardo, Papanicolaou Andrew
Department of Pediatrics, Division of Child and Adolescent Neurology, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
J Child Neurol. 2010 May;25(5):556-66. doi: 10.1177/0883073809344743. Epub 2010 Mar 18.
To investigate the significance of electroencephalogram (EEG) discharges and their treatment, we retrospectively reviewed the charts of 22 children with atypical cognitive development that did not respond to standard educational therapy and demonstrated discharges on EEG. Most children demonstrated no obvious symptoms of seizures, and developmental regression and/or fluctuations were uncommon. The majority of children demonstrated a language and attention disorder and autism symptomatology and had multifocal discharges on EEGs. Of the 20 patients treated with antiepileptic medications, 70% demonstrated definite improvement within 1 clinic visit. This study suggests that children with EEG discharges and developmental cognitive disorders demonstrate a unique pattern of symptomatology and discharges on EEG. This study suggests that children with developmental cognitive disorders that do not respond to standard therapy may benefit from screening with an EEG and a trial of antiepileptic mediation if discharges are detected.
为了研究脑电图（EEG）放电情况及其治疗的意义，我们回顾性分析了22例非典型认知发育儿童的病历，这些儿童对标准教育疗法无反应且脑电图显示有放电现象。大多数儿童无明显癫痫症状，发育倒退和/或波动情况并不常见。大多数儿童表现出语言和注意力障碍以及自闭症症状，脑电图有多处放电。在20例接受抗癫痫药物治疗的患者中，70%在1次门诊就诊内显示出明显改善。本研究表明，脑电图有放电现象且患有发育性认知障碍的儿童表现出独特的症状模式和脑电图放电情况。本研究表明，对标准疗法无反应的发育性认知障碍儿童，若检测到放电，可能通过脑电图筛查和抗癫痫药物试验而获益。
