Mabey D C, Bailey R L, Dunn D, Jones D, Williams J H, Whittle H C, Ward M E
Department of Clinical Sciences, London School of Hygiene and Tropical Medicine.
J Clin Pathol. 1991 Apr;44(4):285-9. doi: 10.1136/jcp.44.4.285.
In an attempt to understand the pathogenesis of corneal changes and conjunctival scarring in trachoma, which are responsible for blindness in some 7 million people worldwide, the surface expression of major histocompatibility complex class II antigens on conjunctival epithelial cells was sought in patients with different clinical features of the disease. Class II expression was significantly associated with active (inflammatory) trachoma, but an independent association with corneal pannus or conjunctival scarring could not be shown. Longitudinal data suggest that class II expression may antedate clinically active disease and persist after it has resolved.
为了了解沙眼导致角膜病变和结膜瘢痕形成的发病机制（全球约700万人因沙眼失明），研究人员在患有不同临床特征沙眼的患者中，探寻结膜上皮细胞上主要组织相容性复合体II类抗原的表面表达情况。II类抗原表达与活动性（炎性）沙眼显著相关，但未发现其与角膜血管翳或结膜瘢痕形成存在独立关联。纵向数据表明，II类抗原表达可能在临床活动性疾病出现之前就已存在，并在疾病消退后持续存在。
