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考虑在异基因干细胞移植后接种 HPV 疫苗。

Time to consider HPV vaccination after allogeneic stem cell transplantation.

机构信息

Long- Term Follow-up Transplant Clinic (LTTC), Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-5505, USA.

出版信息

Biol Blood Marrow Transplant. 2010 Aug;16(8):1033-6. doi: 10.1016/j.bbmt.2010.03.007. Epub 2010 Mar 17.

Abstract

Squamous cell carcinoma (SCC) is among the most common secondary cancers after allogeneic stem cell transplantation (allo-SCT). Several types of human papillomavirus (HPV) are causally linked with SCC of the genital tract and head and neck, and the incidence of these cancers is higher among immunosuppressed patients compared to immunocompetent patients. In June 2006, a quadrivalent HPV vaccine was approved by the Food and Drug Administration (FDA) for females aged 9 to 26 years to prevent cervical warts and vulvar, vaginal, and cervical cancer. FDA approval was granted in October 2009 for males aged 9 to 26 years to prevent genital warts. The quadrivalent HPV vaccine is now available for off-label use, and may be beneficial to patients after allo-SCT. It is time to evaluate the immunogenicity and efficacy in preventing HPV-related squamous cell carcinoma in this population.

摘要

鳞状细胞癌 (SCC) 是异基因造血干细胞移植 (allo-SCT) 后最常见的继发性癌症之一。几种类型的人乳头瘤病毒 (HPV) 与生殖道、头颈部 SCC 有因果关系,与免疫功能正常的患者相比,免疫抑制患者的这些癌症发病率更高。2006 年 6 月,食品和药物管理局 (FDA) 批准了一种四价 HPV 疫苗,用于预防 9 至 26 岁女性的宫颈疣、外阴、阴道和宫颈癌。2009 年 10 月,FDA 批准 9 至 26 岁男性用于预防生殖器疣。目前四价 HPV 疫苗已被批准用于超适应证使用,对 allo-SCT 后的患者可能有益。现在是评估该人群 HPV 相关鳞状细胞癌的免疫原性和疗效的时候了。

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