Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA.
Curr Opin Neurobiol. 2010 Apr;20(2):150-5. doi: 10.1016/j.conb.2010.02.006. Epub 2010 Mar 18.
Accumulating evidence suggests that the synchronization of neuronal activity plays an important role in memory formation. In particular, several recent studies have demonstrated that enhanced synchronous activity within and among medial temporal lobe structures is correlated with increased memory performance in humans and animals. Modulations in rhythmic synchronization in the gamma-frequency (30-100 Hz) and theta-frequency (4-8 Hz) bands have been related to memory performance, and interesting relationships have been described between these oscillations that suggest a mechanism for inter-areal coupling. Neuronal synchronization has also been linked to spike timing-dependent plasticity, a cellular mechanism thought to underlie learning and memory. The available evidence suggests that neuronal synchronization modulates memory performance as well as potential cellular mechanisms of memory storage.
越来越多的证据表明，神经元活动的同步对记忆的形成起着重要作用。特别是，最近的几项研究表明，内侧颞叶结构内部和之间增强的同步活动与人类和动物记忆表现的提高相关。γ频带（30-100 Hz）和θ频带（4-8 Hz）中的节律同步调制与记忆表现相关，并且已经描述了这些振荡之间的有趣关系，表明了区域间耦合的机制。神经元同步也与依赖于尖峰时间的可塑性相关联，这是一种被认为是学习和记忆基础的细胞机制。现有的证据表明，神经元同步调节记忆表现以及记忆存储的潜在细胞机制。
