Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham University, Nottingham, United Kingdom.
Semin Diagn Pathol. 2010 Feb;27(1):49-61. doi: 10.1053/j.semdp.2009.12.009.
Lobular carcinoma is a special type of breast cancer that shows distinct clinical presentation, morphologic and molecular features, and clinical behavior, and its incidence is rising in recent years. Infiltrating lobular carcinoma (ILC) and its precursor lesions may result in diagnostic difficulties, particularly in the screening settings and their management may be problematic. Variants of lobular carcinoma, such as the pleomorphic variant, although not common, exist and some show differences in behavior warranting their recognition in view of requirements for different management strategies. Here we present a review of lobular carcinomas with particular attention to lobular in situ lesions, epidemiology, subtypes, diagnosis, molecular pathology, and grading of ILC in addition to the clinical behavior, response to therapy, and outcome of patients with ILC.
乳腺小叶癌是一种特殊类型的乳腺癌，具有独特的临床表现、形态学和分子特征以及临床行为，其发病率近年来呈上升趋势。乳腺小叶浸润癌（ILC）及其前病变可能导致诊断困难，特别是在筛查环境中，其管理可能存在问题。小叶癌的变体，如多形性变体，虽然不常见，但存在，并且一些在行为上存在差异，鉴于需要不同的管理策略，值得认识到这些差异。在这里，我们回顾了乳腺小叶癌，特别关注乳腺小叶原位病变、流行病学、亚型、诊断、分子病理学以及 ILC 的分级，此外还讨论了 ILC 患者的临床行为、对治疗的反应和结局。
