Division of Orthopedic Surgery, the Affiliated Hospital of Qinghai University, 810001, Xining, Qinghai Province, China.
Afr Health Sci. 2021 Mar;21(1):82-95. doi: 10.4314/ahs.v21i1.13.
This meta-analysis aimed to investigate whether uric acid lowering treatment can improve β-cell function and insulin sensitivity.
PubMed, Cochrane Library, EMBASE and China Biology Medicine were searched up to March 1, 2020. Randomized controlled clinical trials of urate lowering therapy in hyperuricemia patients were included in meta-analysis. Effect size was estimated as mean difference with 95% confidence interval (CI).
Our search yielded 7 eligible trials with 503 participants. This meta-analysis showed that uric acid-lowering therapy decreased fasting insulin -1.43 µIU/ml (weighted mean differences (WMD, 95% CI -2.78 to -0.09), homeostasis model assessment of insulin resistance -0.65 (WMD, 95% CI -1.05 to -0.24), systolic blood pressure -2.45 mm Hg (WMD, 95%CI -4.57 to -0.33) and diastolic blood pressure -3.41 mm Hg (WMD, 95%CI -3.87 to -2.95). However, the treatment had no significant effect on fasting plasma glucose (WMD -0.19 mmol/L, 95%CI -0.42 to 0.05), homeostasis model assessment of β-cell function index (WMD -0.02, 95%CI -0.28 to 0.24), total cholesterol (WMD 0.18 mg/dl; 95%CI, -1.39 to 1.75) and triglyceride (WMD 3.15 mg/dl, 95% CI -9.83 to 16.14).
Uric acid-lowering therapies might improve insulin sensitivity and lower blood pressure, but had no significant effect on HOMA-β and serum lipids.
本荟萃分析旨在探讨尿酸降低治疗是否能改善β细胞功能和胰岛素敏感性。
检索PubMed、Cochrane Library、EMBASE 和中国生物医学文献数据库，检索时间截至 2020 年 3 月 1 日。纳入高尿酸血症患者降尿酸治疗的随机对照临床试验进行荟萃分析。使用均数差（95%置信区间）作为效应量。
共检索到 7 项符合条件的试验，包含 503 名参与者。荟萃分析显示，降尿酸治疗降低空腹胰岛素 1.43µIU/ml（加权均数差（WMD），95%置信区间（CI）-2.78 至-0.09），胰岛素抵抗评估的稳态模型-0.65（WMD，95%CI-1.05 至-0.24），收缩压-2.45mmHg（WMD，95%CI-4.57 至-0.33）和舒张压-3.41mmHg（WMD，95%CI-3.87 至-2.95）。然而，该治疗对空腹血糖（WMD-0.19mmol/L，95%CI-0.42 至 0.05）、胰岛素β细胞功能指数评估的稳态模型（WMD-0.02，95%CI-0.28 至 0.24）、总胆固醇（WMD 0.18mg/dl；95%CI，-1.39 至 1.75）和甘油三酯（WMD 3.15mg/dl，95%CI-9.83 至 16.14）无显著影响。
尿酸降低疗法可能改善胰岛素敏感性并降低血压，但对 HOMA-β 和血清脂质无显著影响。
