Sander O, Sunderkötter C, Kötter I, Wagner I, Becker M, Herrgott I, Schwarting A, Ostendorf B, Iking-Konert C, Genth E
Klinik für Endokrinologie, Diabetologie und Rheumatologie, Heinrich-Heine-Universität Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Deutschland.
Z Rheumatol. 2010 May;69(3):253-62. doi: 10.1007/s00393-010-0618-0.
Capillaroscopy has high diagnostic and prognostic value in autoimmune connective tissue diseases, in particular systemic sclerosis (SSc). Our working group has developed a consensus on nomenclature, technical equipment, procedure, and diagnostic interpretation of results. The following are required: binocular microscopes with at least 20-/50- and 160-/200-fold magnification and digital archiving. Documentation of defined findings is mandatory. The simultaneous occurrence of, e.g. caliber variations, ectasia, ramifications, elongation (length > 350 microm), torsion (at least two crossing segments per capillary loop), sludge, hemorrhage, and edema is of pathological significance. The isolated occurrence of bushy capillaries (multiple ramifications), thrombosis, giant capillary (capillary lumen > 50 microm), and avascular areas also indicates disease. The latter two findings are highly specific for SSc. Other findings are consistent with connective tissue diseases. These standardized definitions increase quality and comparability of nailfold capillaroscopy in Germany.
毛细血管镜检查在自身免疫性结缔组织疾病，尤其是系统性硬化症（SSc）中具有很高的诊断和预后价值。我们的工作组已就命名法、技术设备、操作程序以及结果的诊断解读达成了共识。以下是所需条件：具有至少20/50倍和160/200倍放大倍数的双目显微镜以及数字存档。必须记录明确的检查结果。例如，管径变化、扩张、分支、伸长（长度>350微米）、扭曲（每个毛细血管袢至少有两个交叉段）、血流淤滞、出血和水肿同时出现具有病理意义。丛生毛细血管（多个分支）、血栓形成、巨大毛细血管（毛细血管腔>50微米）和无血管区的单独出现也提示疾病。后两项发现对SSc具有高度特异性。其他发现与结缔组织疾病相符。这些标准化定义提高了德国甲襞毛细血管镜检查的质量和可比性。
