Simay D A, Peskin G W, Saik R P
Am J Dig Dis. 1978 Feb;23(2):169-72. doi: 10.1007/BF01073195.
The effect of metiamide on acid secretion and calcium uptake by the frog gastric mucosa was tested alone and in combination with histamine, pentagastrin, aminophylline, and dibutyrl cyclic AMP (db cAMP). Metiamide inhibited all stimulants including db cAMP which presumably acts intracellularly beyond the H2 receptor. Metiamide, therefore, actively inhibits at a point within the cell beyond the adenylated cyclase membrane receptor complexes. Metiamide also increases calcium influx into the parietal cell, suggesting yet another possible mechanism of inhibition.
分别单独以及与组胺、五肽胃泌素、氨茶碱和二丁酰环磷腺苷（db cAMP）联合使用时，测试了甲硫米特对青蛙胃黏膜酸分泌和钙摄取的影响。甲硫米特抑制所有刺激物，包括db cAMP，而db cAMP可能在细胞内H2受体之外发挥作用。因此，甲硫米特在细胞内腺苷酸环化酶膜受体复合物之外的某一点上发挥积极抑制作用。甲硫米特还增加了壁细胞的钙内流，提示了另一种可能的抑制机制。
