Hemmer J, Kreidler J, Thein T, Haase S
Department of Oral and Maxillofacial Surgery, University of Ulm, FRG.
Chemotherapy. 1991;37(2):150-6. doi: 10.1159/000238848.
Twenty-two patients with squamous cell carcinoma of the oral cavity were treated intra-arterially with epirubicin and cisplatin. Biopsies were taken before, during, and after treatment and analysed by DNA flow cytometry. Clinical response to therapy was better in the diploid group as well as in previously aneuploid tumors which showed complete disappearance of the abnormal clone in the course of treatment. Poor reduction of tumor volume corresponded with persistence of aneuploid cells.
22例口腔鳞状细胞癌患者接受了表柔比星和顺铂动脉内治疗。在治疗前、治疗期间和治疗后进行活检，并通过DNA流式细胞术进行分析。二倍体组以及先前非整倍体肿瘤在治疗过程中异常克隆完全消失的患者对治疗的临床反应较好。肿瘤体积缩小不佳与非整倍体细胞的持续存在有关。
