Neumann-Haefelin D, Sundmacher R, Wochnik G, Bablok B
Arch Ophthalmol. 1978 Jan;96(1):64-9. doi: 10.1001/archopht.1978.03910050028007.
In a continuous series of 457 patients with presumed herpetic eye disease, virus isolation and typing revealed 154 patients with herpes simplex virus type 1 and three patients with type 2 infections. In 219 isolates that were examined for neutralization by specific antisera, for growth in human fibroblasts, and, in part, for temperature sensitivity, there were found substantial strain differences in addition to the type-specific characteristics. The clinical features of each of the three type 2 infections are described in detail. A suggestive correlation found between clinical courses and virus growth characteristics of the type 1 strains indicates that further virologic differentiation of these strains would be useful.
在连续的457例疑似疱疹性眼病患者中，病毒分离和分型显示154例为1型单纯疱疹病毒感染，3例为2型感染。在对219株分离株进行的检测中，通过特异性抗血清中和、在人成纤维细胞中培养以及部分检测温度敏感性，发现除了型特异性特征外，还存在显著的菌株差异。详细描述了3例2型感染患者的临床特征。1型菌株的临床病程与病毒生长特征之间存在提示性关联，表明对这些菌株进行进一步的病毒学区分将是有用的。
