磷米多辛的分离与特性研究。一种新型抗真菌核苷酸抗生素。
Isolation and characterization of phosmidosine. A new antifungal nucleotide antibiotic.
作者信息
Uramoto M, Kim C J, Shin-Ya K, Kusakabe H, Isono K, Phillips D R, McCloskey J A
机构信息
Antibiotics Laboratory, RIKEN, Institute of Physical and Chemical Research, Saitama, Japan.
出版信息
J Antibiot (Tokyo). 1991 Apr;44(4):375-81. doi: 10.7164/antibiotics.44.375.
A new nucleotide antibiotic, phosmidosine was isolated from a culture filtrate of a newly isolated streptomycete identified as Streptomyces sp. RK-16. HRFAB-MS and elemental analysis established the molecular formula of C16H24N7O8P. 1H, 13C and 31P NMR indicated the presence of a methyl phosphate group and UV spectra were similar to those of 8-hydroxyadenosine. The antibiotic inhibited spore formation of Botrytis cinerea at the concentration of 0.25 micrograms/ml.
一种新的核苷酸类抗生素——磷米多星，是从一株新分离的链霉菌（鉴定为链霉菌属RK-16）的培养滤液中分离得到的。高分辨快原子轰击质谱（HRFAB-MS）和元素分析确定其分子式为C16H24N7O8P。氢谱（1H NMR）、碳谱（13C NMR）和磷谱（31P NMR）表明存在一个磷酸甲酯基团，紫外光谱与8-羟基腺苷的紫外光谱相似。该抗生素在浓度为0.25微克/毫升时可抑制灰葡萄孢的孢子形成。
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