曲古霉素B，一种来自链霉菌的多烯大环内酯类抗生素。

Trichomycin B, a polyene macrolide from Streptomyces.

作者信息

Komori T

机构信息

Research and Technology Group, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.

出版信息

J Antibiot (Tokyo). 1990 Jul;43(7):778-82. doi: 10.7164/antibiotics.43.778.

DOI:10.7164/antibiotics.43.778

Abstract

Two polyene macrolide, trichomycins A and B, were compared by physico-chemical and microbiological methods. The two antibiotics were found to have the same molecular formula, C58H84N2O18 (MW 1,096), by elemental analysis and FAB-MS. However, 1H and 13C NMR spectrometry studies indicated that the hydroxyl at C-5 of trichomycin A located on C-9 in trichomycin B. Trichomycin B possessed lower activities against fungi and yeasts than those of trichomycin A.

摘要

通过物理化学和微生物学方法对两种多烯大环内酯类抗生素曲古霉素A和B进行了比较。通过元素分析和快原子轰击质谱法发现，这两种抗生素具有相同的分子式C58H84N2O18（分子量1096）。然而，1H和13C核磁共振光谱研究表明，曲古霉素A中C-5位的羟基在曲古霉素B中位于C-9位。曲古霉素B对真菌和酵母的活性低于曲古霉素A。

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