曲古霉素B，一种来自链霉菌的多烯大环内酯类抗生素。

Trichomycin B, a polyene macrolide from Streptomyces.

作者信息

Komori T

机构信息

Research and Technology Group, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.

出版信息

J Antibiot (Tokyo). 1990 Jul;43(7):778-82. doi: 10.7164/antibiotics.43.778.

DOI:10.7164/antibiotics.43.778

Abstract

Two polyene macrolide, trichomycins A and B, were compared by physico-chemical and microbiological methods. The two antibiotics were found to have the same molecular formula, C58H84N2O18 (MW 1,096), by elemental analysis and FAB-MS. However, 1H and 13C NMR spectrometry studies indicated that the hydroxyl at C-5 of trichomycin A located on C-9 in trichomycin B. Trichomycin B possessed lower activities against fungi and yeasts than those of trichomycin A.

摘要

通过物理化学和微生物学方法对两种多烯大环内酯类抗生素曲古霉素A和B进行了比较。通过元素分析和快原子轰击质谱法发现，这两种抗生素具有相同的分子式C58H84N2O18（分子量1096）。然而，1H和13C核磁共振光谱研究表明，曲古霉素A中C-5位的羟基在曲古霉素B中位于C-9位。曲古霉素B对真菌和酵母的活性低于曲古霉素A。

相似文献

1

Trichomycin B, a polyene macrolide from Streptomyces.曲古霉素B，一种来自链霉菌的多烯大环内酯类抗生素。

J Antibiot (Tokyo). 1990 Jul;43(7):778-82. doi: 10.7164/antibiotics.43.778.

2

Trichomycin A, a heptaene macrolide: isolation and characterization.曲古霉素A，一种七烯大环内酯类抗生素：分离与表征。

J Antibiot (Tokyo). 1990 Jul;43(7):904-6. doi: 10.7164/antibiotics.43.904.

3

Tetrin C, a new glycosylated polyene macrolide antibiotic produced by Streptomyces sp. GK9244.特曲菌素C，一种由链霉菌属GK9244产生的新型糖基化多烯大环内酯类抗生素。

J Nat Prod. 1999 Jun;62(6):917-9. doi: 10.1021/np9805645.

4

Secondary metabolites by chemical screening: II. Amycins A and B two novel niphimycin analogs isolated from a high producer strain of elaiophylin and nigericin.通过化学筛选获得的次生代谢产物：II. 阿霉素A和B，从高产伊索菌素和尼日利亚菌素菌株中分离出的两种新型尼菲霉素类似物。

J Antibiot (Tokyo). 1990 Jun;43(6):639-47. doi: 10.7164/antibiotics.43.639.

5

Neo-enactin, a new antifungal antibiotic potentiating polyene antifungal antibiotics. I. Fermentation, extraction, purification and physico-chemical and biological properties.新制霉菌素，一种增强多烯类抗真菌抗生素作用的新型抗真菌抗生素。I. 发酵、提取、纯化及理化和生物学性质

J Antibiot (Tokyo). 1979 Jan;32(1):13-7. doi: 10.7164/antibiotics.32.13.

6

RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. I. Taxonomy, fermentation, isolation and biological activities.RS - 22A、B和C：来自紫色链霉菌的新型大环内酯类抗生素。I. 分类学、发酵、分离及生物活性

J Antibiot (Tokyo). 1995 Apr;48(4):289-92. doi: 10.7164/antibiotics.48.289.

7

N'-methylniphimycin, a novel minor congener of niphimycin from Streptomyces spec. 57-13.N'-甲基尼菲霉素，一种来自链霉菌属57-13的新型尼菲霉素次要同系物。

J Basic Microbiol. 1998;38(5-6):415-9. doi: 10.1002/(sici)1521-4028(199811)38:5/6<415::aid-jobm415>3.0.co;2-z.

8

Fermentation, isolation, purification and biological activity of SJA-95, a heptaene polyene macrolide antibiotic produced by the Streptomyces sp. strain S24.链霉菌属S24菌株产生的七烯多烯大环内酯类抗生素SJA-95的发酵、分离、纯化及生物活性

Arzneimittelforschung. 2007;57(3):171-9. doi: 10.1055/s-0031-1296601.

9

Isolation and characterization of phosmidosine. A new antifungal nucleotide antibiotic.磷米多辛的分离与特性研究。一种新型抗真菌核苷酸抗生素。

J Antibiot (Tokyo). 1991 Apr;44(4):375-81. doi: 10.7164/antibiotics.44.375.

10

Mycotrienin, a new polyene antibiotic isolated from Streptomyces.霉菌三烯菌素，一种从链霉菌中分离出的新型多烯抗生素。

J Antibiot (Tokyo). 1967 Nov;20(6):329-33.

引用本文的文献

1

The stereostructure of candicidin D.杀念菌素D的立体结构。

J Antibiot (Tokyo). 2015 Aug;68(8):504-10. doi: 10.1038/ja.2015.17. Epub 2015 Feb 25.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验