Howard Hughes Medical Institute, Denver, CO, USA.
Immunology. 2010 May;130(1):10-5. doi: 10.1111/j.1365-2567.2010.03260.x. Epub 2010 Mar 16.
Immunological memory is one of the features that define the adaptive immune response: by generating specific memory cells after infection or vaccination, the host provides itself with a set of cells and molecules that can prevent future infections and disease. Despite the obvious importance of memory cells, memory CD4 T cells are incompletely understood. Here we discuss recent progress in understanding which activated T cells surmount the barrier to enter into the memory pool and, once generated, what signals are important for memory cell survival. There is still, however, little understanding of how (or even whether) memory CD4 T cells are useful once they have been created; a surprising thought considering the critical role CD4 T cells play in all adaptive primary immune responses. In light of this, we will discuss how CD4 T memory T cells respond to reactivation in vivo and whether they are malleable to a re-assignment of their effector response.
通过在感染或接种疫苗后产生特定的记忆细胞，宿主为自己提供了一组可以预防未来感染和疾病的细胞和分子。尽管记忆细胞的重要性显而易见，但记忆 CD4 T 细胞的理解并不完全。在这里，我们讨论了理解哪些激活的 T 细胞克服进入记忆池的障碍的最新进展，以及一旦产生，哪些信号对记忆细胞存活很重要。然而，对于记忆 CD4 T 细胞一旦被创造出来后如何（甚至是否）有用，人们的了解仍然很少；考虑到 CD4 T 细胞在所有适应性原发性免疫反应中所起的关键作用，这是一个令人惊讶的想法。有鉴于此，我们将讨论 CD4 T 记忆 T 细胞如何对体内再激活作出反应，以及它们是否可以重新分配其效应器反应。
