帕金森病伴发重性抑郁障碍患者的认知-行为治疗。
Cognitive-behavioral therapy for patients with Parkinson's disease and comorbid major depressive disorder.
机构信息
Depression Clinical & Research Program, Department of Neurology, Massachusetts General Hospital, 15 Parkman St., Wac 812, Boston, MA 02114, USA.
出版信息
Psychosomatics. 2010 Mar-Apr;51(2):124-9. doi: 10.1176/appi.psy.51.2.124.
BACKGROUND
Depression has been recognized as a common feature of Parkinson's disease (PD), and is the most prevalent psychiatric disorder in PD patients.
OBJECTIVE
The authors sought to determine whether cognitive-behavioral therapy (CBT) is effective in the treatment of depression within the context of PD (dPD).
METHOD
The authors enrolled 8 depressed PD patients into an open treatment study of 12 weeks of individual CBT treatment.
RESULTS
There was a significant linear decrease in mean Hamilton Rating Scale for Depression (17-item) scores over Weeks 0 to 12, and 57% of patients (4/7) met criteria for remission at endpoint.
CONCLUSION
This uncontrolled study suggests that CBT may be effective in treating dPD and may be an alternative or adjunct to pharmacological treatment.
背景
抑郁症已被认为是帕金森病（PD）的常见特征，也是 PD 患者中最常见的精神障碍。
目的
作者试图确定认知行为疗法（CBT）在 PD 背景下（dPD）治疗抑郁症是否有效。
方法
作者招募了 8 名患有抑郁症的 PD 患者，对他们进行为期 12 周的个体 CBT 治疗的开放性治疗研究。
结果
汉密尔顿抑郁量表（17 项）评分从 0 周到 12 周呈显著线性下降，57%的患者（4/7）在终点时符合缓解标准。
结论
这项非对照研究表明，CBT 可能对治疗 dPD 有效，可能是药物治疗的替代或辅助手段。
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