Division of Infectious Diseases, Hsinchu Cathay General Hospital, Hsinchu City, Taiwan.
Epidemiol Infect. 2011 Feb;139(2):275-85. doi: 10.1017/S0950268810000634. Epub 2010 Mar 25.
Noroviruses are an important aetiological agent of acute gastroenteritis. They are responsible for large outbreaks of disease in the community, hospitals and long-term-care facilities. The clinical manifestations of norovirus outbreaks in psychiatric units are rarely described. The disease burden and impact highlight the importance of timely notification and investigation of these outbreaks. We analysed the characteristics of four norovirus outbreaks which occurred during a 3-year period in an in-patient psychiatric care unit. A total of 184 patients were affected which included 172 hospitalized patients, seven healthcare workers (HCWs) and five psychiatric nursing-home residents. The mean incidence rate of norovirus gastroenteritis (NVG) in hospitalized patients during these outbreaks was 12·7%. These outbreaks were characterized by higher incidence in middle-aged male patients, predominant sickness of diarrhoea, short duration of illness, peaks in late winter and early spring, and higher susceptibility in acute psychiatric patients. HCWs had longer duration of illness than psychiatric patients. More than 10% of affected patients experienced ≥ 2 infections. Infection control measures were instituted and a comprehensive, responsive standard operating procedure for NVG and outbreak management was developed. After implementation of these measures, no further outbreaks of NVG occurred during the study period.
诺如病毒是急性肠胃炎的重要病因。它们是导致社区、医院和长期护理机构大规模疾病爆发的原因。精神科病房中诺如病毒爆发的临床表现很少被描述。疾病负担和影响突出表明及时通知和调查这些爆发的重要性。我们分析了在住院精神病护理病房 3 年内发生的四起诺如病毒爆发的特征。共有 184 名患者受到影响,包括 172 名住院患者、7 名医护人员(HCWs)和 5 名精神病养老院居民。这些爆发中住院患者诺如病毒肠胃炎(NVG)的发病率平均为 12.7%。这些爆发的特征是中年男性患者发病率较高,腹泻为主,病程短,冬末春初发病高峰,急性精神病患者易感性较高。HCWs 的疾病持续时间比精神病患者长。超过 10%的受影响患者经历了≥2 次感染。已采取感染控制措施,并制定了 NVG 和爆发管理的全面、响应式标准操作程序。在实施这些措施后,在研究期间没有发生进一步的 NVG 爆发。