Negus S Stevens, Bilsky Edward J, Do Carmo Gail Pereira, Stevenson Glenn W
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Methods Mol Biol. 2010;617:79-91. doi: 10.1007/978-1-60327-323-7_7.
Pain-depressed behavior can be defined as any behavior that decreases in rate, frequency, duration, or intensity in response to a putative pain state. Common examples include pain-related decreases in feeding, locomotion and expression of positively reinforced operant behavior. In humans, depression of behavior is often accompanied by a comorbid depression of mood. Measurements of pain-depressed behaviors are used to diagnose pain in both human and veterinary medicine, and restoration of pain-depressed behavior is often a priority of treatment. This article describes two strategies for integrating measures of pain-depressed behaviors into preclinical assays of pain and analgesia. Assays of pain-depressed behaviors may contribute both to improved translational efficiency in analgesic drug development and to new insights regarding the mechanisms and determinants of pain and analgesia.
疼痛抑制行为可定义为因假定的疼痛状态而导致速率、频率、持续时间或强度降低的任何行为。常见的例子包括与疼痛相关的进食减少、运动减少以及阳性强化操作性行为的表达减少。在人类中，行为抑制通常伴有共病的情绪低落。疼痛抑制行为的测量用于诊断人类和兽医学中的疼痛，恢复疼痛抑制行为通常是治疗的首要任务。本文描述了将疼痛抑制行为测量纳入疼痛和镇痛临床前试验的两种策略。疼痛抑制行为的试验可能有助于提高镇痛药开发的转化效率，并有助于对疼痛和镇痛的机制及决定因素有新的认识。
