单相抑郁症并不影响对甜味测试的反应。
Unipolar depression does not moderate responses to the Sweet Taste Test.
机构信息
Department of Psychiatry, Department of Psychiatry, University of North Carolina School of Medicine, 101 Manning Drive, Chapel Hill, NC 27599-3366, USA.
出版信息
Depress Anxiety. 2010 Sep;27(9):859-63. doi: 10.1002/da.20690.
BACKGROUND
The Sweet Taste Test (STT) measures hedonic responses to sweet tastes and has been linked to both alcoholism and to a family history of alcoholism. However, STT response profiles in unipolar major depressive disorder (MDD), a disorder characterized by anhedonia, have been minimally investigated.
METHODS
Twelve adults with and 15 adults without MDD participated in two identical STT assessments separated by approximately 12 weeks. Between assessments, MDD outpatients received Behavioral Activation Therapy for Depression, a psychotherapy modality designed to increase engagement with rewarding stimuli and reduce avoidance behaviors. Primary-dependent measures included sensitivity to sucrose, hedonic response to sucrose, and designation as a Sweet-Liker or Sweet-Disliker.
RESULTS
A total of 75% of adults with MDD were treatment responders. There were no significant differences in STT response profiles between groups overall or at either timepoint. Furthermore, STT profiles of MDD participants did not differ after psychotherapy, relative to baseline.
CONCLUSIONS
Findings suggest that although anhedonia is a symptom of MDD, the disorder is not characterized by altered responses to sweet tastes. Implications and future directions are discussed.
背景
甜味测试（STT）测量对甜味的愉悦反应，与酗酒和酗酒家族史有关。然而，在以快感缺失为特征的单相重性抑郁障碍（MDD）中，对 STT 反应特征的研究很少。
方法
12 名伴有和 15 名不伴 MDD 的成年人参加了两次完全相同的 STT 评估，两次评估间隔约 12 周。在评估之间，MDD 门诊患者接受了抑郁的行为激活治疗，这是一种旨在增加对奖励刺激的参与和减少回避行为的心理治疗模式。主要依赖的测量包括对蔗糖的敏感性、对蔗糖的愉悦反应，以及被指定为“甜喜好者”或“甜不喜好者”。
结果
共有 75%的 MDD 成年人是治疗反应者。总体而言，或在任何时间点，两组之间的 STT 反应特征均无显著差异。此外，与基线相比，MDD 参与者在接受心理治疗后，STT 特征并无差异。
结论
研究结果表明，尽管快感缺失是 MDD 的症状之一，但该疾病的特征不是对甜味的反应改变。讨论了其意义和未来方向。
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