Department of Plastic, Hand and Reconstructive Surgery, Medizinische Hochschule Hannover, Hannover, Germany.
Clin Exp Dermatol. 2010 Jun;35(4):437-9. doi: 10.1111/j.1365-2230.2010.03779.x. Epub 2010 Mar 10.
Photoageing is generally treated by ablative procedures that injure the epidermis and basement membrane, and lead to fibrosis of the dermis. Percutaneous collagen induction (PCI) therapy is an alternative treatment for photoaged skin that does not result in clinical signs of dermal fibrosis. In this study, the immediate effects of PCI on the skin were assessed, including the systemic inflammatory response and the production and gene expression of transforming growth factor (TGF) isoforms beta1, beta2 and beta3. Eighty rats were split into four groups: group 1 (n = 24; PCI plus skin care); group 2 (n = 24; skin care only); group 3 (n = 24; PCI only) and group 4 (n = 8; controls). Microarray analysis showed that TGF-beta3, an essential marker for preventing scarring, was upregulated and expressed for 2 weeks postoperatively. PCI might offer a regenerative therapy to improve skin appearance and quality and to improve or even prevent scarring.
光老化通常通过损伤表皮和基底膜的消融性程序进行治疗，导致真皮纤维化。经皮胶原诱导（PCI）治疗是一种替代光老化皮肤的治疗方法，不会导致皮肤纤维化的临床迹象。在这项研究中，评估了 PCI 对皮肤的即刻影响，包括全身炎症反应以及转化生长因子（TGF）同工型β1、β2 和β3 的产生和基因表达。80 只大鼠分为四组：第 1 组（n = 24；PCI 加皮肤护理）；第 2 组（n = 24；仅皮肤护理）；第 3 组（n = 24；仅 PCI）和第 4 组（n = 8；对照组）。微阵列分析显示，TGF-β3 是一种预防瘢痕形成的重要标志物，术后 2 周内上调并表达。PCI 可能提供一种再生疗法，以改善皮肤外观和质量，并改善甚至预防瘢痕形成。
