Department of Psychology, University of Gothenburg, SE-405 30 Gothenburg, Sweden.
Int Psychogeriatr. 2010 Jun;22(4):598-606. doi: 10.1017/S1041610210000335. Epub 2010 Mar 26.
The epsilon4 allele of the apolipoprotein E (APOE) gene and low levels of cerebrospinal fluid (CSF) amyloid beta-proteins 42 (Abeta) have previously been associated with increased risk of cognitive decline in old age. In this study we examine the interaction of these markers with episodic memory in a sample identified as having mild cognitive impairment (MCI).
The sample (N = 149) was drawn from the Gothenburg MCI study and measured according to three free recall tests on three occasions spanning over four years. Second-order Latent Curve Models (LCM) were fitted to the data.
Analyses accounting for age, gender, education, APOE, Abeta42, and interaction between APOE and Abeta42 revealed that the epsilon4 allele was significantly associated with level of memory performance in the presence of low Abeta42 values (< or = 452 ng/L). Associations between memory performance and Abeta42 were significant among the epsilon4 carriers but not among the non-carriers. The Abeta42 marker was, however, significantly associated with changes in memory over the study time period in the total sample.
The findings support the hypothesis of an interactive effect of APOE and Abeta42 for memory decline in MCI patients.
载脂蛋白 E（APOE）基因的 epsilon4 等位基因和脑脊液（CSF）中低水平的淀粉样蛋白 beta 蛋白 42（Abeta）先前与老年认知能力下降的风险增加有关。在这项研究中，我们在被确定为轻度认知障碍（MCI）的样本中检查了这些标志物与情景记忆的相互作用。
该样本（N=149）取自哥德堡 MCI 研究，并根据三个自由回忆测试在跨越四年的三个时间点进行测量。二阶潜在曲线模型（LCM）用于拟合数据。
考虑到年龄、性别、教育、APOE、Abeta42 以及 APOE 和 Abeta42 之间的相互作用进行的分析表明，在 Abeta42 值较低（<或=452ng/L）的情况下，epsilon4 等位基因与记忆表现水平显著相关。在 epsilon4 携带者中，记忆表现与 Abeta42 之间存在显著相关性，但在非携带者中则没有。然而，Abeta42 标志物与整个样本在研究期间记忆变化显著相关。
这些发现支持了 APOE 和 Abeta42 对 MCI 患者记忆下降的相互作用假说。
