Department of Pathology and Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Am J Pathol. 2010 May;176(5):2107-12. doi: 10.2353/ajpath.2010.090656. Epub 2010 Mar 26.
Heterologous immunity associated with cross-reactive T-cell responses is proposed to contribute to variations among individuals in the pathogenesis of human viral infections. In genetically identical mice with similar infection histories, marked variations in the magnitude and specificities of T-cell responses under conditions of heterologous immunity occur and have been linked to the private specificity of T-cell repertoires in individual immune mice. Variations in immunopathology in the form of panniculitis are observed in lymphocytic choriomeningitis virus-immune mice after vaccinia virus infection. By adoptively transferring splenocytes from individual lymphocytic choriomeningitis virus-immune donors into paired recipients, we show here that, on vaccinia virus infection, similar levels of panniculitis were generated in recipients from a single donor, but the severity of panniculitis varied among recipients receiving cells from different donors. This indicates that virus-induced immunopathology under conditions of heterologous immunity is a function of the private specificity of the immune repertoire.
异源免疫与交叉反应性 T 细胞反应有关，据推测它有助于个体间人类病毒感染发病机制的差异。在具有相似感染史的遗传上相同的小鼠中，在异源免疫条件下 T 细胞反应的幅度和特异性存在明显差异，并且与个体免疫小鼠 T 细胞库的特异性有关。在淋巴细胞性脉络丛脑膜炎病毒免疫小鼠感染牛痘病毒后，观察到以脂膜炎形式出现的免疫病理学变化。通过从个体淋巴细胞性脉络丛脑膜炎病毒免疫供体中过继转移脾细胞，我们在此表明，在牛痘病毒感染后，来自单个供体的受体会产生相似水平的脂膜炎，但来自不同供体的细胞的受体会出现脂膜炎的严重程度不同。这表明，异源免疫条件下的病毒诱导免疫病理学是免疫库的特异性的功能。
