评估不相关病毒之间的非互惠异源免疫。
Evaluation of non-reciprocal heterologous immunity between unrelated viruses.
作者信息
Che Jenny W, Selin Liisa K, Welsh Raymond M
机构信息
Department of Pathology, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605-2324, USA.
Department of Pathology, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605-2324, USA.
出版信息
Virology. 2015 Aug;482:89-97. doi: 10.1016/j.virol.2015.03.002. Epub 2015 Mar 31.
Abstract
Heterologous immunity refers to the phenomenon whereby a history of an immune response against one pathogen can provide a level of immunity to a second unrelated pathogen. Previous investigations have shown that heterologous immunity is not necessarily reciprocal, such as in the case of vaccinia virus (VACV). Replication of VACV is reduced in mice immune to a variety of pathogens, while VACV fails to induce immunity to several of the same pathogens, including lymphocytic choriomeningitis virus (LCMV). Here we examine the lack of reciprocity of heterologous immunity between VACV and LCMV and find that they induce qualitatively different memory CD8 T cells. However, depending on the repertoire of an individual host, VACV can provide protection against LCMV simply by experimentally amplifying the quantity of T cells cross-reactive with the two viruses. Thus, one cause for lack of reciprocity is differences in the frequencies of cross-reactive T cells in immune hosts.
摘要
异源免疫是指针对一种病原体的免疫反应史能够为第二种不相关病原体提供一定程度免疫力的现象。先前的研究表明，异源免疫不一定是相互的，例如牛痘病毒（VACV）的情况。在对多种病原体免疫的小鼠中，VACV的复制会减少，而VACV无法诱导对几种相同病原体的免疫，包括淋巴细胞性脉络丛脑膜炎病毒（LCMV）。在这里，我们研究了VACV和LCMV之间异源免疫缺乏相互性的情况，发现它们诱导的记忆性CD8 T细胞在性质上有所不同。然而，根据个体宿主的T细胞库，VACV可以通过实验性地增加与这两种病毒交叉反应的T细胞数量来提供对LCMV的保护。因此，缺乏相互性的一个原因是免疫宿主中交叉反应性T细胞频率的差异。
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