Bernardes Sara S, Borges Isabele K, Lima Juliana E, Milanez Paula de Azevedo O, Conchon-Costa Ivete, Felipe Ionice, Saridakis Halha O, Watanabe Maria A E
Laboratory of Pathology, Biological Science Center, State University of Londrina, Paraná, Brasil.
Curr HIV Res. 2010 Jun;8(4):340-6. doi: 10.2174/157016210791208613.
Recently, a mechanism of negative regulation of immune responses by a specialized population of so-called regulatory T cells (Tregs) has become a focus of intense investigation. Through the discovery of transcription factor Foxp3 as a central molecular determinant of Tregs differentiation and function, the complex biology of these cells, including maintenance of immunological tolerance to "self" and regulation of immune responses to pathogens, commensals, and tumors, has become the focus of intense investigation. The ability to control the infection and to delay the progression of the infection to AIDS and/or death is probably regulated by a balance between host factors, such as immunologic response and viral factors. Different rates of disease progression among HIV-1 infected individuals have been observed. In this context, Tregs may play an important role in the immunopathology of HIV-1 infection due to their potent suppressive activity of both T cell activation and effector function. In this review, we present the molecular and immunological aspects of Tregs in the HIV system and the association between Tregs and highly active antiretroviral therapy (HAART).
最近，一种由所谓的调节性T细胞（Tregs）特殊群体对免疫反应进行负调节的机制已成为深入研究的焦点。通过发现转录因子Foxp3作为Tregs分化和功能的核心分子决定因素，这些细胞的复杂生物学特性，包括对“自身”免疫耐受的维持以及对病原体、共生菌和肿瘤免疫反应的调节，已成为深入研究的焦点。控制感染以及延缓感染进展至艾滋病和/或死亡的能力可能受宿主因素（如免疫反应）和病毒因素之间平衡的调节。已观察到HIV-1感染个体之间疾病进展速度不同。在这种情况下，由于Tregs对T细胞活化和效应功能具有强大的抑制活性，它们可能在HIV-1感染的免疫病理学中发挥重要作用。在本综述中，我们介绍了HIV系统中Tregs的分子和免疫学方面以及Tregs与高效抗逆转录病毒疗法（HAART）之间的关联。
