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DNA 测序和线性探针检测比较利福布汀敏感性和多药耐药结核分枝杆菌 rpoB 基因突变。

Comparison of rifabutin susceptibility and rpoB mutations in multi-drug-resistant Mycobacterium tuberculosis strains by DNA sequencing and the line probe assay.

机构信息

Clinical Research Center, National Hospital Organization, Kinki-chuo Chest Medical Center, 1180 Nagasone-cho, Sakai, 591-8555, Japan.

出版信息

J Infect Chemother. 2010 Oct;16(5):360-3. doi: 10.1007/s10156-010-0057-5. Epub 2010 Mar 31.

DOI:10.1007/s10156-010-0057-5
PMID:20354890
Abstract

We compared rifabutin susceptibility and rpoB mutations in 98 multi-drug-resistant strains of Mycobacterium tuberculosis (MDR-TB) by DNA sequencing and with a line probe assay using the commercially available INNO-LiPA Rif. TB kit (the LiPA). Our results indicated that rifabutin continues to remain active against MDR-TB strains harboring certain genetic alterations and also that the LiPA might be useful in identifying MDR-TB strains susceptible to rifabutin.

摘要

我们通过 DNA 测序和使用市售的 INNO-LiPA Rif. TB 试剂盒（LiPA）进行线探针杂交试验比较了 98 株耐多药结核分枝杆菌（MDR-TB）对利福布汀的敏感性和 rpoB 突变。结果表明，利福布汀对携带某些遗传改变的 MDR-TB 菌株仍然有效，并且 LiPA 可能有助于鉴定对利福布汀敏感的 MDR-TB 菌株。

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