Meng Da-Hai, Xu Yong-Ping, Chen Wen-Liang, Zou Jian, Lou Li-Guang, Zhao Wei-Min
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
J Asian Nat Prod Res. 2007 Sep-Dec;9(6-8):679-84. doi: 10.1080/10286020601103270.
Bioassay-guided fractionation of the crude extract of Mitrephora thorelii (Annonaceae) led to the isolation of two clerodane-type diterpenes. Their structures were characterised on the basis of spectroscopic methods as 6alpha,16,18-trihydroxycleroda-3(4),13(14)-dien-15,16-olide (1) and 16-hydroxycleroda-3(4),13(14)-dien-15,16-olide (2). Compound 1 is a new compound. Compounds 1 and 2 exhibited inhibitory activity against the proliferation of human hepatoma BEL-7402 cells in vitro. Compound 2 also showed an in vivo anti-tumour effect against the growth of hepatoma H22 in mice.
对多蕊暗罗（番荔枝科）粗提物进行生物测定导向的分离，得到了两种克罗烷型二萜。通过光谱方法确定它们的结构分别为6α,16,18 - 三羟基克罗达 - 3(4),13(14) - 二烯 - 15,16 - 内酯（1）和16 - 羟基克罗达 - 3(4),13(14) - 二烯 - 15,16 - 内酯（2）。化合物1是一种新化合物。化合物1和2在体外对人肝癌BEL - 7402细胞的增殖具有抑制活性。化合物2在体内对小鼠肝癌H22的生长也显示出抗肿瘤作用。
