来自金合欢属植物的新二萜类化合物及其细胞毒性活性。
New diterpenoids from Caesalpinia species and their cytotoxic activity.
机构信息
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India.
出版信息
Bioorg Med Chem Lett. 2010 May 1;20(9):2847-50. doi: 10.1016/j.bmcl.2010.03.048. Epub 2010 Mar 12.
Chemical investigation on Caesalpinia crista afforded two new diterpenoids, 6beta-cinnamoyloxy-7beta-acetoxyvouacapen-5alpha-ol and 6beta,7beta-dibenzoyloxyvouacapen-5alpha-ol and on Caesalpiniapulcherrima another new diterpenoid, 12-demethyl neocaesalpin F along with several known constituents. The structures of the new compounds were settled from their 1D and 2D NMR spectral data. The cytotoxicity of these compounds was measured on two different cancer cell lines.
对金缕梅科植物决明（Caesalpinia crista）和美丽云实属植物美丽云实（Caesalpiniapulcherrima）的化学成分研究分别得到了两个新的二萜化合物，6β-肉桂酰氧基-7β-乙酰氧基渥卡林-5α-醇和 6β，7β-二苯甲酰氧基渥卡林-5α-醇，以及另一个新的二萜化合物，12-去甲基新槐属 F，同时还分离得到了几种已知成分。这些新化合物的结构是根据它们的 1D 和 2D NMR 光谱数据确定的。测定了这些化合物对两种不同癌细胞系的细胞毒性。
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