School of Biotechnology, Yeungnam University, 214-1 Dae-dong, Gyeongsan, Gyeongbuk 712-749, South Korea.
Bioorg Med Chem Lett. 2010 Jan 1;20(1):288-90. doi: 10.1016/j.bmcl.2009.10.116. Epub 2009 Nov 17.
Two novel neo-clerodane diterpenoids, barbatellarines A (1) and B (2), were isolated from the whole plants of Scutellaria barbata, along with the known compound scutebarbatine F (3). The chemical structures and relative stereochemistry of the isolated compounds were established by NMR (1D and 2D) and mass spectroscopic analyses. Compounds 2 and 3 were evaluated for in vitro cytotoxic activity against the HL-60 (human leukemia), MCF7 (human breast cancer), and LLC (Lewis lung carcinoma) cancer cell lines. Compound 2 exhibited weak cytotoxic activity against HL-60 cells, with an IC(50) value of 41.4microM.
从巴天酸模全草中分离得到了两个新的 neo-clerodane 二萜类化合物，巴塔林 A（1）和 B（2），以及已知化合物 scutebarbatine F（3）。通过 NMR（1D 和 2D）和质谱分析确定了分离化合物的化学结构和相对立体化学。对化合物 2 和 3 进行了体外细胞毒性活性评价，针对 HL-60（人白血病）、MCF7（人乳腺癌）和 LLC（Lewis 肺癌）癌细胞系。化合物 2 对 HL-60 细胞表现出较弱的细胞毒性活性，IC50 值为 41.4μM。
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