球孢子菌病中 IgM 血清学假阳性。

False-positive IgM serology in coccidioidomycosis.

机构信息

Infection Prevention Program/Quality Management, John C. Lincoln Health Network, 2423 West Dunlap Avenue, Suite 100, Phoenix, AZ 85021, USA.

出版信息

J Clin Microbiol. 2010 Jun;48(6):2047-9. doi: 10.1128/JCM.01843-09. Epub 2010 Mar 31.

DOI:10.1128/JCM.01843-09

PMID:20357210

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2884478/

Abstract

The clinical observation has been made that there might be an unacceptable number of false-positive enzyme immunoassay (EIA) test results for IgM among persons suspected of having coccidioidomycosis. Patients with a positive result for IgM by EIA are thought to have a diagnosis of acute coccidioidomycosis. However, this study found that 82% of patients with an IgM-positive and IgG-negative EIA result did not have coccidioidomycosis.

摘要

临床观察发现，疑似球孢子菌病的人群中，酶免疫分析（EIA）检测 IgM 可能会出现不可接受数量的假阳性结果。通过 EIA 检测 IgM 呈阳性的患者被认为患有急性球孢子菌病。然而，本研究发现，EIA 结果 IgM 阳性而 IgG 阴性的患者中，有 82%的人并未患有球孢子菌病。