Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2010 Apr;25(4):509-16. doi: 10.3346/jkms.2010.25.4.509. Epub 2010 Mar 19.
The objective of this study was to identify the factors that determine serum homocysteine concentrations in Korean population. In a community-based study, 871 participants completed detailed questionnaires and physical examination. We found that increased age, male sex, family history of stroke, deficiencies of serum folate and vitamin B12, and elevated serum creatinine significantly increased the risk of hyperhomocysteinemia. However, hormonal and behavioral factors (smoking, alcohol drinking, coffee consumption, and sedentary time) were not associated with the risk of hyperhomocysteinemia. The risk of hyperhomocysteinemia was steeply increased in subjects with two or more risk factors among four selected risk factors (deficiencies of serum folate and vitamin B12, elevated creatinine, and family history of stroke) compared to subjects who did not have any risk factors, especially subjects over the age of 65 yr (odds ratio [OR], 33.5; 95% confidence interval [CI], 3.71-302.0 in men; OR, 39.2; 95% CI, 7.95-193.2 in women). In conclusion, increased age, male sex, family history of stroke, deficiencies of serum folate and vitamin B12, and elevated serum creatinine are important determinants of serum homocysteine concentrations with interaction effects between these factors.
本研究旨在确定韩国人群血清同型半胱氨酸浓度的决定因素。在一项基于社区的研究中，871 名参与者完成了详细的问卷调查和体检。我们发现，年龄增长、男性、中风家族史、血清叶酸和维生素 B12 缺乏以及血清肌酐升高显著增加了高同型半胱氨酸血症的风险。然而，激素和行为因素（吸烟、饮酒、喝咖啡和久坐时间）与高同型半胱氨酸血症的风险无关。与没有任何风险因素的受试者相比，在四个选定风险因素（血清叶酸和维生素 B12 缺乏、肌酐升高和中风家族史）中存在两个或更多风险因素的受试者中，高同型半胱氨酸血症的风险急剧增加，尤其是年龄在 65 岁以上的受试者（男性的比值比 [OR]，33.5；95%置信区间 [CI]，3.71-302.0；女性的 OR，39.2；95%CI，7.95-193.2）。总之，年龄增长、男性、中风家族史、血清叶酸和维生素 B12 缺乏以及血清肌酐升高是血清同型半胱氨酸浓度的重要决定因素，这些因素之间存在相互作用。
