Plant Biotechnology Research Center, School of Agriculture and Biology, Fudan-SJTU-Nottingham Plant Biotechnology R&D Center, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
Appl Microbiol Biotechnol. 2010 May;86(6):1707-17. doi: 10.1007/s00253-010-2546-y. Epub 2010 Apr 1.
In the urgent search for more effective ways to treat cancer, new extraction methods of taxol from endophytic fungus have demonstrated high potential in increasing the efficiency of taxol extraction for more efficient and sustainable production of taxol and cancer treatment products. This paper summarizes recent advances in taxol-producing endophytic fungi, both in China and abroad, in the following areas: isolation and identification of endophytic fungi types, extraction and detection methods of endophytic taxol in plants, and improved efficiency of the extraction process. With the advancement of science and technology, new techniques in biotechnology, such as fungal strain improvement and recombining technique and microbial fermentation engineering, have increased the extraction yield from taxol-producing fungi, thereby improved the overall efficiency of taxol production.
在迫切寻求更有效的癌症治疗方法的过程中，从内生真菌中提取紫杉醇的新方法在提高紫杉醇提取效率方面显示出了很大的潜力，有助于更高效、更可持续地生产紫杉醇和癌症治疗产品。本文综述了国内外在以下方面产紫杉醇内生真菌的最新进展：内生真菌类型的分离和鉴定、植物内生紫杉醇的提取和检测方法以及提取过程效率的提高。随着科学技术的进步，生物技术领域的新技术，如真菌菌株改良和重组技术以及微生物发酵工程，提高了产紫杉醇真菌的提取产量，从而提高了紫杉醇生产的整体效率。
