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局部应用0.5%半胱胺清除肾病性胱氨酸病患者角膜中的晶体。

Clearance of corneal crystals in nephropathic cystinosis by topical cysteamine 0.5%.

作者信息

Jones N P, Postlethwaite R J, Noble J L

机构信息

Manchester University, Department of Ophthalmology.

出版信息

Br J Ophthalmol. 1991 May;75(5):311-2. doi: 10.1136/bjo.75.5.311.

DOI:10.1136/bjo.75.5.311
PMID:2036352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1042364/
Abstract

A 2-year-old girl with nephropathic cystinosis was successfully treated with topical cysteamine 0.5% to one eye. Clearance of crystals from the treated cornea was virtually complete after three months. The possibilities and limitations of this form of treatment are discussed.

摘要

一名患有肾病型胱氨酸病的2岁女孩，使用0.5%的半胱胺滴眼液对一只眼睛进行局部治疗，取得了成功。三个月后，治疗的角膜上的晶体几乎完全清除。本文讨论了这种治疗方式的可能性和局限性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beed/1042364/76560f66f2c8/brjopthal00567-0056-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beed/1042364/eacd16e7fe5b/brjopthal00567-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beed/1042364/76560f66f2c8/brjopthal00567-0056-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beed/1042364/eacd16e7fe5b/brjopthal00567-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beed/1042364/76560f66f2c8/brjopthal00567-0056-b.jpg

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本文引用的文献

1
Removal of corneal crystals by topical cysteamine in nephropathic cystinosis.在肾病性胱氨酸病中，通过局部应用半胱胺去除角膜晶体。
N Engl J Med. 1987 Mar 26;316(13):775-9. doi: 10.1056/NEJM198703263161304.
2
Glare disability in nephropathic cystinosis.肾病性胱氨酸病中的眩光障碍
Arch Ophthalmol. 1987 Dec;105(12):1670-1. doi: 10.1001/archopht.1987.01060120068026.
3
Spatial and temporal sequence of corneal crystal deposition in nephropathic cystinosis.肾病性胱氨酸病中角膜晶体沉积的空间和时间序列。
接受医院药房自制半胱胺滴眼液制剂的胱氨酸病患者的眼部状况：病例系列
Ophthalmol Ther. 2019 Mar;8(1):125-136. doi: 10.1007/s40123-018-0156-4. Epub 2018 Dec 5.
4
Cysteamine hydrochloride eye drop solution for the treatment of corneal cystine crystal deposits in patients with cystinosis: an evidence-based review.用于治疗胱氨酸病患者角膜胱氨酸晶体沉积的盐酸半胱胺滴眼液：一项循证综述
Clin Ophthalmol. 2018 Jan 24;12:227-236. doi: 10.2147/OPTH.S133516. eCollection 2018.
5
Clinical Practice: A Proposed Standardized Ophthalmological Assessment for Patients with Cystinosis.临床实践：针对胱氨酸病患者的拟标准化眼科评估
Ophthalmol Ther. 2017 Jun;6(1):93-104. doi: 10.1007/s40123-017-0089-3. Epub 2017 May 5.
6
A case of corneal cystinosis in a patient with rickets and chronic renal failure.一名患有佝偻病和慢性肾衰竭患者的角膜胱氨酸病病例。
Indian J Ophthalmol. 2015 Oct;63(10):785-7. doi: 10.4103/0301-4738.171509.
7
Treatment of corneal cystine crystal accumulation in patients with cystinosis.胱氨酸病患者角膜胱氨酸晶体积聚的治疗
Clin Ophthalmol. 2014 Oct 10;8:2077-84. doi: 10.2147/OPTH.S36626. eCollection 2014.
8
Evaluation of topical cysteamine therapy in the CTNS(-/-) knockout mouse using in vivo confocal microscopy.使用体内共聚焦显微镜评估CTNS（-/-）基因敲除小鼠的局部半胱胺治疗效果。
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Mol Vis. 2011;17:2212-20. Epub 2011 Aug 17.
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N Engl J Med. 1987 Apr 16;316(16):971-7. doi: 10.1056/NEJM198704163161602.
6
Long-term ocular manifestations in nephropathic cystinosis.肾病型胱氨酸病的长期眼部表现
Arch Ophthalmol. 1986 May;104(5):706-11. doi: 10.1001/archopht.1986.01050170096030.
7
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Am J Ophthalmol. 1987 Aug 15;104(2):190-1. doi: 10.1016/0002-9394(87)90018-3.
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A randomized placebo-controlled trial of cysteamine eye drops in nephropathic cystinosis.一项关于半胱胺滴眼液治疗肾病性胱氨酸病的随机安慰剂对照试验。
Arch Ophthalmol. 1990 May;108(5):689-93. doi: 10.1001/archopht.1990.01070070075038.