Department of Gastrointestinal Surgery Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Cytokine. 2010 Jun;50(3):328-34. doi: 10.1016/j.cyto.2010.03.008. Epub 2010 Apr 3.
Previous studies suggested the relationship between interleukin (IL)-8 -251 A/T gene polymorphism and risk of gastric cancer (GC). However, the currently available results were not consistent. The present study aimed to quantitatively analyse this association using a meta-analysis. Published literature from PubMed, EMBASE and CNKI (China Knowledge Resource Integrated Database) were retrieved. Twelve case-control studies with 3012 cases of GC and 3893 controls were included. Overall, IL-8 -251 A/T polymorphism was not associated with the risk of GC. However, when stratified for ethnicity/country, the results showed that A allele carriers had an increased risk of GC while T allele carriers had a decreased risk of GC in Korean people. When stratified for Helicobacter pylori infection, the results showed that A allele carriers with H. pylori infection had an increased risk of GC while T allele carriers with or without H. pylori infection had a decreased risk of GC. When stratified for tumor location and histological type (Lauren's classification), A allele carriers had an increased risk of intestinal- and diffuse-type of GC and non-cardia cancer, while T allele carriers had a decreased risk of intestinal- and diffuse-type of GC and non-cardia cancer. These results suggest that overall IL-8 -251 A/T gene polymorphism is not associated with the risk of GC and the association may be varied according to histological type, tumor location, H. pylori infection and ethnicity/country. More well-designed studies based on larger population are needed to confirm our results and further evaluate the association between IL-8 -251 A/T gene polymorphism and gastric cancer.
先前的研究表明白细胞介素 (IL)-8 -251 A/T 基因多态性与胃癌 (GC) 的风险之间存在关联。然而，目前的结果并不一致。本研究旨在通过荟萃分析定量分析这种关联。检索了 PubMed、EMBASE 和 CNKI（中国知识资源综合数据库）中的已发表文献。共纳入了 12 项病例对照研究，包括 3012 例胃癌病例和 3893 例对照。总体而言，IL-8 -251 A/T 多态性与 GC 风险无关。然而，按种族/国家分层时，结果显示 A 等位基因携带者患 GC 的风险增加，而 T 等位基因携带者患 GC 的风险降低在韩国人群中。按幽门螺杆菌感染分层时，结果显示 A 等位基因携带者感染幽门螺杆菌时患 GC 的风险增加，而 T 等位基因携带者无论是否感染幽门螺杆菌，患 GC 的风险均降低。按肿瘤部位和组织学类型（Lauren 分类）分层时，A 等位基因携带者患肠型和弥漫型 GC 和非贲门癌的风险增加，而 T 等位基因携带者患肠型和弥漫型 GC 和非贲门癌的风险降低。这些结果表明，总体而言，IL-8 -251 A/T 基因多态性与 GC 的风险无关，这种关联可能因组织学类型、肿瘤部位、幽门螺杆菌感染和种族/国家而异。需要更多基于更大人群的精心设计的研究来证实我们的结果，并进一步评估 IL-8 -251 A/T 基因多态性与胃癌之间的关联。
